The Medical School, The University of Sheffield, Sheffield, United Kingdom.
Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
Ann Thorac Surg. 2020 Sep;110(3):e173-e175. doi: 10.1016/j.athoracsur.2020.01.044. Epub 2020 Mar 2.
It is a well-described phenomenon in the literature that a thymoma can lead to aplastic anemia, and that a thymectomy can be curative for to aplastic anemia. However, the opposite is extremely rare. We present an unusual case of a 60-year-old woman with myasthenia gravis, who was diagnosed with an incidental thymoma found on computerized tomography. Resection of the thymoma treated her myasthenia gravis but led to an aplastic anemia resistant to granulocyte colony-stimulating factor, cyclosporin, and horse antithymocyte globulin treatment. The patient received an allogenic stem cell transplant but unfortunately passed away because of complications.
文献中有充分描述,胸腺瘤可导致再生障碍性贫血,胸腺切除术对再生障碍性贫血可能具有治疗作用。然而,相反的情况极为罕见。我们报告了一例不常见的病例,一名 60 岁女性患有重症肌无力,在计算机断层扫描检查中偶然发现胸腺瘤。切除胸腺瘤治疗了她的重症肌无力,但导致再生障碍性贫血,对粒细胞集落刺激因子、环孢素和马抗胸腺细胞球蛋白治疗耐药。患者接受了同种异体干细胞移植,但不幸因并发症去世。