Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.
Instituto de Tumores e Cuidados Paliativos de Cuiabá do Hospital Geral e Maternidade de Cuiabá, Cuiabá, MT, Brazil.
Clin Immunol. 2020 Apr;213:108373. doi: 10.1016/j.clim.2020.108373. Epub 2020 Mar 2.
Inflammation is a colorectal cancer (CRC) hallmark. Inflammasome-dependent cytokines IL-1ß and IL-18 can play a beneficial or detrimental role in tumorigenesis depending on cancer type. Variants in inflammasome genes were associated with tumor development and/or outcome, and have been proposed as potential biomarkers for population screening. In this study, 215 CRC patients followed-up for 10 years were examined for 9 polymorphisms in selected inflammasome genes. Multivariate association analysis and survival analysis were performed to evaluate the association between the polymorphisms and CRC prognosis. Variants associated with lower levels of IL-18 (rs1834481, rs5744256), or with increased activation of inflammasome receptors NLRP1 (rs12150220) and NLRP3 (rs35829419) resulted detrimental to CRC prognosis and may be used as prognostic markers.
炎症是结直肠癌（CRC）的一个标志。炎性小体依赖性细胞因子 IL-1β 和 IL-18 可以根据癌症类型在肿瘤发生中发挥有益或有害的作用。炎性小体基因的变异与肿瘤的发展和/或结果相关，并被提议作为人群筛查的潜在生物标志物。在这项研究中，对 215 名随访 10 年的 CRC 患者进行了 9 种选定炎性小体基因的多态性检查。进行了多变量关联分析和生存分析，以评估多态性与 CRC 预后之间的关联。与较低水平的 IL-18（rs1834481、rs5744256）相关的变异，或与炎性小体受体 NLRP1（rs12150220）和 NLRP3（rs35829419）的激活增加相关的变异，对 CRC 的预后不利，可作为预后标志物。
