NLRP1 L155H多态性是子痫前期发生的一个风险因素。
NLRP1 L155H Polymorphism is a Risk Factor for Preeclampsia Development.
作者信息
Pontillo Alessandra, Reis Edione C, Bricher Pamela N, Vianna Priscila, Diniz Solange, Fernandes Karla S, Chies Jose A, Sandrim Valeria
机构信息
Laboratory of Immunogenetics, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo/USP, Sao Paulo, SP, Brazil.
Laboratory of Immunogenetics, Department of Genetics, Federal University of Rio Grande do Sul/UFRS, Porto Alegre, RS, Brazil.
出版信息
Am J Reprod Immunol. 2015 Jun;73(6):577-81. doi: 10.1111/aji.12353. Epub 2014 Dec 29.
PROBLEM
Augmented levels of IL-1ß have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1ß cleavage and IL-1ß secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome' genes and preeclampsia.
METHOD OF STUDY
Selected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia.
RESULTS AND CONLCLUSIONS
The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR = 1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.
问题
白细胞介素-1β（IL-1β）水平升高已被指出是子痫前期发展的重要致病因素。炎性小体是负责前白细胞介素-1β切割和IL-1β分泌的细胞质复合物。本研究的目的是评估炎性小体基因多态性与子痫前期之间的关联。
研究方法
对286例患有子痫前期和309例未患子痫前期的巴西女性，分析炎性小体基因（NLRP1、NLRP3、CARD8和IL1B）中的选定多态性。
结果与结论
NLRP1变体rs12150220（L155H）与子痫前期的发生有关（比值比=1.58），提示该炎性小体受体在这种多因素疾病的发病机制中起作用。
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