Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Mental Health Center, Translational Neuroscience Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Sleep Research Laboratory, Center for Integrative Neuroscience and Inflammatory Diseases, Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, VA, USA.
Sleep Med Rev. 2020 Jun;51:101281. doi: 10.1016/j.smrv.2020.101281. Epub 2020 Feb 11.
Polysomnographic studies have been conducted to explore sleep changes in Parkinson's disease (PD), but the relationships between sleep disturbances and PD are imperfectly understood. We conducted a systematic review of the literature exploring polysomnographic differences between PD patients and controls in EMBASE, MEDLINE, All EBM databases, CINAHL, and PsycIFNO. 67 studies were identified for systematic review, 63 of which were used for meta-analysis. Meta-analyses revealed significant reductions in total sleep time, sleep efficiency, N2 percentage, slow wave sleep, rapid eye movement sleep (REM) percentage, and increases in wake time after sleep onset, N1 percentage, REM latency, apnea hypopnea index, and periodic limb movement index in PD patients compared with controls. There were no remarkable differences in sleep continuity or sleep architecture between PD patients with and without REM sleep behavior disorder (RBD). Our study suggests that PD patients have poor sleep quality and quantity. Sex, age, disease duration, presence of RBD, medication status, cognitive impairment, and adaptation night are factors that contributed to heterogeneity between studies.
进行了多项多导睡眠图研究，以探索帕金森病（PD）中的睡眠变化，但对睡眠障碍与 PD 之间的关系仍了解不充分。我们在 EMBASE、MEDLINE、所有 EBM 数据库、CINAHL 和 PsycINFO 中对文献进行了系统综述，以探索 PD 患者与对照组之间多导睡眠图的差异。确定了 67 项系统综述研究，其中 63 项用于荟萃分析。荟萃分析显示，与对照组相比，PD 患者的总睡眠时间、睡眠效率、N2 百分比、慢波睡眠、快速眼动睡眠（REM）百分比减少，睡眠潜伏期、呼吸暂停低通气指数和周期性肢体运动指数增加。PD 患者的睡眠连续性或睡眠结构与 REM 睡眠行为障碍（RBD）患者无显著差异。我们的研究表明，PD 患者的睡眠质量和数量较差。性别、年龄、疾病持续时间、RBD 存在、用药情况、认知障碍和适应夜间是导致研究间异质性的因素。
