Department of Psychological Medicine, University Malaya Medical Centre, 59100, Kuala Lumpur, Malaysia.
Department of Psychiatry, Hospital Raja Permaisuri Bainun, 30450, Ipoh, Perak, Malaysia.
Asian J Psychiatr. 2020 Apr;50:101986. doi: 10.1016/j.ajp.2020.101986. Epub 2020 Feb 26.
Electroconvulsive therapy (ECT) is safe and efficacious in the elderly population. However, clinicians are still weary to use it among the old-old population, citing safety concerns. Our case report highlights the use of ECT in a 91 year old lady with late onset Bipolar Mania.
A 91 year old lady presented with an acute manic relapse for the past 2 weeks. She was previously on oral Sodium Valproate, and during this current admission was augmented with oral Quetiapine IR 100 mg bd. She remained unwell and was planned for right unilateral ECT with age-based dosing stimuli. After only 4 sessions, she showed complete resolution of her manic symptoms.
In our case study, the patient showed rapid response to right unilateral ECT. Even though the Post Suppression Index (PSI) was not significant, there is some evidence that in elderly patients, burst suppression (not measured in this case) may be more accurate measure of ECT efficacy. The transient treatment emergent delirium was short lived and ECT was very tolerated in this patient.
Clinicians should not delay ECT in old-old patients who do not respond to pharmacologic treatment, as early switch to ECT results in rapid response with good safety profile.
电抽搐疗法(ECT)在老年人群中是安全有效的。然而,临床医生在为老老年人群使用 ECT 时仍持谨慎态度,主要是出于对安全性的担忧。我们的病例报告强调了在一位 91 岁患有迟发性双相情感障碍躁狂症的女性中使用 ECT。
一位 91 岁的女士在过去 2 周内出现急性躁狂复发。她之前服用口服丙戊酸钠,此次入院时加用口服喹硫平 IR 100mg 每日两次。她的病情仍未好转,计划进行右侧单侧 ECT,并根据年龄调整刺激剂量。仅进行了 4 次治疗后,她的躁狂症状完全缓解。
在我们的病例研究中,患者对右侧单侧 ECT 快速反应。尽管后抑制指数(PSI)不显著,但有证据表明,在老年患者中,爆发抑制(本病例未测量)可能是 ECT 疗效更准确的衡量标准。短暂的治疗性谵妄持续时间短,且该患者对 ECT 耐受性良好。
对于那些对药物治疗无反应的老老年患者,临床医生不应延迟 ECT 的使用,因为早期转为 ECT 可快速起效,且安全性良好。