Chiba A, Torroba M, Honma Y, Zapata A G
Department of Biology, Nippon Dental University, Niigata, Japan.
Am J Anat. 1988 Nov;183(3):268-76. doi: 10.1002/aja.1001830309.
The cytoarchitecture of the lymphohaemopoietic masses occurring in the "meninx primitiva" of the stingray Dasyatis akajei (Elasmobranchii, Chondricthyes) has been analyzed by light and scanning and transmission electron microscopy. Lymphohaemopoietic aggregates showing similar morphologies occurred along all the central nervous system, but they were more frequent in the telencephalon, diencephalon, and mesencephalon. In each aggregate, the granulopoietic tissue appeared in a fibroblastic stroma surrounding the large blood vessels, and the lymphoid components were present in a reticular network. Developing and mature eosinophils and heterophils--as well as lymphocytes, monocytes, macrophages, and plasma cells--are the main free cells present in these meningeal aggregates. The remarkable intimate association between macrophages and lymphoid cells to form close cell clusters suggests some immunological capacity for the meningeal lymphohaemopoietic tissue. According to their capacities, presence of lymphoid tissue, and histological organization, the meningeal lymphohemopoietic aggregates of Dasyatis akajei resemble other lymphomyeloid aggregates associated with cranium and choroid plexuses in Holocephali and Ganoidei. The phylogenetical relationships of these aggregates with mammalian bone marrow are discussed.
通过光学显微镜、扫描电子显微镜和透射电子显微镜，对赤魟（软骨鱼纲，板鳃亚纲）“原始脑膜”中出现的淋巴造血组织的细胞结构进行了分析。沿整个中枢神经系统均出现了形态相似的淋巴造血聚集体，但在端脑、间脑和中脑更为常见。在每个聚集体中，粒细胞生成组织出现在围绕大血管的成纤维细胞基质中，淋巴样成分则存在于网状网络中。正在发育和成熟的嗜酸性粒细胞和嗜中性粒细胞，以及淋巴细胞、单核细胞、巨噬细胞和浆细胞，是这些脑膜聚集体中主要的游离细胞。巨噬细胞与淋巴样细胞之间形成紧密细胞簇的显著紧密关联，提示脑膜淋巴造血组织具有一定的免疫能力。根据其功能、淋巴样组织的存在情况以及组织学结构，赤魟的脑膜淋巴造血聚集体类似于全头亚纲和硬鳞鱼纲中与颅骨和脉络丛相关的其他淋巴髓样聚集体。本文还讨论了这些聚集体与哺乳动物骨髓的系统发育关系。
