Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Tukholmankatu 8, 00290 Helsinki, Finland.
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland.
Int J Mol Sci. 2020 Mar 3;21(5):1739. doi: 10.3390/ijms21051739.
Calcium (Ca) is perhaps the most versatile signaling molecule in cells. Ca regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1-7. In man, six functional forms are expressed (TRPC1, TRPC3-7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion.
钙（Ca）也许是细胞中用途最广泛的信号分子。钙调节细胞中大量的关键事件，从基因转录、运动和收缩到能量产生和通道门控。为了完成所有这些不同的功能，需要多种通道、泵和转运体。参与这些过程的一组通道是瞬时受体电位（TRP）家族的阳离子通道。这些通道分为 29 个子家族，在人类、啮齿动物、蠕虫和苍蝇中表达不同。其中一个亚家族是瞬时受体电位经典（TRPC）家族的通道。该离子通道家族由七个异构体组成，标记为 TRPC1-7。在人类中，表达了六种功能性形式（TRPC1、TRPC3-7），而 TRPC2 是假基因；因此，没有功能性表达。在这篇综述中，我们将描述 TRPC 通道及其相互作用的分子伴侣在癌症发病机制中的重要性，特别是在调节迁移和侵袭方面。
