Smani Tarik, Gómez Luis J, Regodon Sergio, Woodard Geoffrey E, Siegfried Geraldine, Khatib Abdel-Majid, Rosado Juan A
Department of Medical Physiology and Biophysic, Institute of Biomedicine of Seville, University of Seville, Sevilla, Spain.
CIBERCV, Madrid, Spain.
Front Physiol. 2018 Dec 3;9:1731. doi: 10.3389/fphys.2018.01731. eCollection 2018.
Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial organization of endothelial cells. This mechanism is regulated by a balance between stimulatory and inhibitory factors. Proangiogenic factors include a variety of VEGF family members, while thrombospondin and endostatin, among others, have been reported as suppressors of angiogenesis. Transient receptor potential (TRP) channels belong to a superfamily of cation-permeable channels that play a relevant role in a number of cellular functions mostly derived from their influence in intracellular Ca homeostasis. Endothelial cells express a variety of TRP channels, including members of the TRPC, TRPV, TRPP, TRPA, and TRPM families, which play a relevant role in a number of functions, including endothelium-induced vasodilation, vascular permeability as well as sensing hemodynamic and chemical changes. Furthermore, TRP channels have been reported to play an important role in angiogenesis. This review summarizes the current knowledge and limitations concerning the involvement of particular TRP channels in growth factor-induced angiogenesis.
血管生成是由内皮细胞的增殖、迁移和空间组织介导的血管生长。这种机制受刺激因子和抑制因子之间平衡的调节。促血管生成因子包括多种血管内皮生长因子（VEGF）家族成员，而血小板反应蛋白和内皮抑素等则被报道为血管生成的抑制剂。瞬时受体电位（TRP）通道属于阳离子通透通道超家族，在许多细胞功能中发挥重要作用，这些功能大多源于它们对细胞内钙稳态的影响。内皮细胞表达多种TRP通道，包括TRPC、TRPV、TRPP、TRPA和TRPM家族的成员，它们在许多功能中发挥重要作用，包括内皮诱导的血管舒张、血管通透性以及感知血流动力学和化学变化。此外，据报道TRP通道在血管生成中起重要作用。本综述总结了关于特定TRP通道参与生长因子诱导的血管生成的当前知识和局限性。
