Department of Chinese Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan.
School of Medicine, National Cheng Kung University Tainan, Taiwan.
Am J Chin Med. 2020;48(2):329-340. doi: 10.1142/S0192415X20500160. Epub 2020 Mar 5.
Dengue fever is an important epidemic disease with a high prevalence in tropical and subtropical countries. We aimed to investigate the effects of a treatment integrating traditional Chinese (TCM) and Western medicines on dengue inpatients with warning signs (i.e., group B) according to the World Health Organization dengue classification in this retrospective cohort study of medical records. Inpatients who were treated with conventional Western therapies in the absence or presence of TCM were assigned to the control and treatment groups, respectively. Data were compared using an analysis of variance, general linear analysis, and chi-square test. The most common clinical symptoms and signs of dengue fever were fever and muscle ache. The treatment group patients were significantly more likely to present general weakness and poor appetite than the control group patients. Patients in the treatment group were more likely to experience stomachache than those in the control group. Moreover, comparisons of the changes in hemoglobin and alanine aminotransferase levels over time revealed significant differences between the patient groups. Zhu Ye Shi Gao Tang, Gui Pi Tang, , and were the most commonly administered TCM formula and single herbs in this study. Patients in the treatment group experienced a resolution of symptoms, signs, and laboratory data and were discharged smoothly, without deterioration to death or critical care. Our findings suggest that the integration of TCM and Western medicine may yield an appropriate treatment for dengue fever.
登革热是一种在热带和亚热带国家流行率较高的重要传染病。我们旨在根据世界卫生组织的登革热分类，通过对病历的回顾性队列研究，调查针对有预警症状（即 B 组）登革热住院患者的中西医结合治疗效果。将接受单纯西医常规治疗或同时接受中医治疗的患者分别分配至对照组和治疗组。采用方差分析、广义线性分析和卡方检验比较数据。登革热最常见的临床症状和体征是发热和肌肉疼痛。与对照组患者相比，治疗组患者更易出现全身乏力和食欲不振。治疗组患者比对照组患者更易出现胃痛。此外，两组患者的血红蛋白和丙氨酸氨基转移酶水平随时间的变化比较显示出显著差异。在本研究中，最常用的中医方剂和单味中药是竹叶石膏汤、归脾汤、 、 。治疗组患者的症状、体征和实验室数据得到缓解，顺利出院，没有恶化至死亡或转入重症监护病房。我们的研究结果表明，中西医结合可能为登革热提供一种合适的治疗方法。
