The office of the top tertiary hospital, Shekou People's Hospital, Nanshan district, Shenzhen, Guangdong Province, China.
Center for Disease Control and Prevention of Changshan County, Quzhou, Zhejiang Province, China.
BMC Public Health. 2020 Mar 6;20(1):295. doi: 10.1186/s12889-020-8428-z.
There was little known on how the interaction effect between obesity and current smoking affected the incidence of hypertension. The aim of this study was to investigate how body mass index (BMI) modified the effect of current smoking on the incidence of hypertension.
Data were obtained from the China Health and Nutrition Survey (CHNS). According to the WHO recommendations for Chinese people, the normal weight, overweight, and obesity were defined using the BMI cutoff values 18.5 kg/m, 23.0 kg/m, and 27.5 kg/m, respectively. Current smokers were defined as having smoked at least 100 cigarettes or electronic cigarettes, 20 cigars, or 20 tobacco pipes and other type of tobacco in the last 30 days preceding the survey. Hypertension was defined as systolic blood pressure (SBP)/ diastolic blood pressure (DBP) ≥ 140/90 mmHg, use of anti-hypertensive medications, or a self-reported diagnosis.
This study included 12,900 subjects. There were interaction effects between obesity and current smoking in females (P = 0.030) and the 50-59 years group (P = 0.049). Current smoking was a significant predictor of incident hypertension only in the total and female populations with normal weight (HR: 1.119 and 1.274; HR 95% CI: 1.013-1.236 and 1.143-1.415; and P = 0.027 and 0.040, respectively). Stratified by age, current smoking affected the development of hypertension only in the 50-59 years subjects with the normal weight (HR: 1.356; HR 95% CI: 1.084-1.697; and P = 0.008).
Current smoking was a significant predictor of incident hypertension only in the female and middle-age populations with normal weight but not in the overweight and obesity as well as the younger and elder populations.
肥胖与当前吸烟之间的交互作用如何影响高血压的发病率知之甚少。本研究旨在探讨体重指数 (BMI) 如何改变当前吸烟对高血压发病率的影响。
数据来自中国健康与营养调查 (CHNS)。根据世界卫生组织对中国人的建议，使用 BMI 截断值 18.5kg/m、23.0kg/m 和 27.5kg/m 将正常体重、超重和肥胖定义。当前吸烟者被定义为在调查前 30 天内至少吸过 100 支香烟或电子烟、20 支雪茄或 20 支烟斗及其他类型的烟草。高血压定义为收缩压（SBP）/舒张压（DBP）≥140/90mmHg、使用抗高血压药物或自我报告的诊断。
本研究共纳入 12900 名受试者。在女性（P=0.030）和 50-59 岁组（P=0.049）中，肥胖和当前吸烟之间存在交互作用。当前吸烟仅在正常体重的总人群和女性人群中是发生高血压的显著预测因素（HR：1.119 和 1.274；HR 95%CI：1.013-1.236 和 1.143-1.415；P=0.027 和 0.040）。按年龄分层，当前吸烟仅影响正常体重的 50-59 岁人群发生高血压（HR：1.356；HR 95%CI：1.084-1.697；P=0.008）。
当前吸烟仅在正常体重的女性和中年人群中是发生高血压的显著预测因素，而在超重和肥胖以及年轻和老年人群中则不是。
