He Kaiyin, Li Yuting, Guo Xin, Zhong Lu, Tang Shaohui
Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, People's Republic of China.
Br J Nutr. 2020 Jul 14;124(1):1-13. doi: 10.1017/S0007114520000914. Epub 2020 Mar 6.
Dietary habits have been implicated in the development and severity of non-alcoholic fatty liver disease (NAFLD). Several epidemiological studies attempted to assess the relationship between food groups and the likelihood of NAFLD, but these results were conflicting. The present meta-analysis was conducted to assess the association between food groups and the likelihood of NAFLD. Published literature was retrieved and screened from MEDLINE, Embase and Web of Science. Out of 7892 retrieved articles, twenty-four observational studies (fifteen cross-sectional studies and nine case–control studies) met our eligibility criteria and were finally included in this systematic review and meta-analysis. Consumption of both red meat and soft drinks contributed to a positive association with NAFLD. Inversely, nut consumption was negatively associated with NAFLD. There were no significant influences on the likelihood of NAFLD about consuming whole grains, refined grains, fish, fruits, vegetables, eggs, dairy products and legumes. This meta-analysis suggests that individuals who consumed more red meat and soft drinks may have a significantly increased likelihood of NAFLD, whereas higher nut intake may be negatively associated with NAFLD. Further prospective studies are required to assess the association between food patterns and NAFLD.
饮食习惯与非酒精性脂肪性肝病（NAFLD）的发生和严重程度有关。多项流行病学研究试图评估食物类别与NAFLD发生可能性之间的关系，但这些结果相互矛盾。本荟萃分析旨在评估食物类别与NAFLD发生可能性之间的关联。从MEDLINE、Embase和科学网检索并筛选已发表的文献。在检索到的7892篇文章中，24项观察性研究（15项横断面研究和9项病例对照研究）符合我们的纳入标准，最终纳入本系统评价和荟萃分析。红肉和软饮料的摄入均与NAFLD呈正相关。相反，食用坚果与NAFLD呈负相关。食用全谷物、精制谷物、鱼类、水果、蔬菜、鸡蛋、乳制品和豆类对NAFLD发生可能性无显著影响。本荟萃分析表明，食用较多红肉和软饮料的个体患NAFLD的可能性可能显著增加，而较高的坚果摄入量可能与NAFLD呈负相关。需要进一步的前瞻性研究来评估饮食模式与NAFLD之间的关联。
