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正常鸡和免疫抑制鸡经鸡败血支原体实验感染的比较

Comparison of Experimental Infection of Normal and Immunosuppressed Chickens with Mycoplasma gallisepticum.

作者信息

Bao J, Wu Z, Ishfaq M, Miao Y, Li R, Clifton A C, Ding L, Li J

机构信息

College of Veterinary Medicine, China.

College of Life Sciences, Northeast Agricultural University, 600 Changjiang Road, Xiangfang District, Harbin, China.

出版信息

J Comp Pathol. 2020 Feb;175:5-12. doi: 10.1016/j.jcpa.2019.12.001. Epub 2020 Jan 9.

Abstract

Four different models of infection of chickens with Mycoplasma gallisepticum (MG) were evaluated. Normal or immunosuppressed chicks (10 days old) were infected with the MG R strain via eye and nasal drops or by direct air sac injection. Bacterial load in the lungs was quantified and air sac and tracheal lesion scores, tracheal mucosal thickness and humoral immune responses were assessed. Serum antibody responses were assessed by use of a serum plate agglutination test. Three days post infection (dpi), all immunosuppressed chicks had developed significant respiratory signs. Chicks infected via air sac injection had significant differences in serum antibody and gross lesion scores at 5 dpi. All chicks had developed pathological changes by 7 dpi. Air sac inoculation of immunosuppressed chicks produced more significant (P ≤0.05) lesions, and these birds had the highest bacterial load in the lungs compared with other groups.

摘要

对鸡感染鸡败血支原体(MG)的四种不同模型进行了评估。正常或免疫抑制的雏鸡(10日龄)通过滴眼和滴鼻或直接气囊注射感染MG R株。对肺部的细菌载量进行定量,并评估气囊和气管病变评分、气管黏膜厚度和体液免疫反应。通过血清平板凝集试验评估血清抗体反应。感染后3天(dpi),所有免疫抑制的雏鸡都出现了明显的呼吸道症状。通过气囊注射感染的雏鸡在感染后5天的血清抗体和大体病变评分有显著差异。所有雏鸡在感染后7天均出现了病理变化。对免疫抑制雏鸡进行气囊接种产生了更显著(P≤0.05)的病变,与其他组相比,这些鸡肺部的细菌载量最高。

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