Department of Radiation Oncology, Sidney Kimmel Medical College & Cancer Center at Thomas Jefferson University, Philadelphia, PA.
Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Francis H. Burr Proton Therapy Center, Boston, MA.
Semin Oncol. 2020 Feb;47(1):8-22. doi: 10.1053/j.seminoncol.2020.02.002. Epub 2020 Feb 21.
Proton radiotherapy has promised an advantage in safely treating pediatric malignancies with an increased capability to spare normal tissues, reducing the risk of both acute and late toxicity. The past decade has seen the proliferation of more than 30 proton facilities in the United States, with increased capacity to provide access to approximately 3,000 children per year who will require radiotherapy for their disease. We provide a review of the initial efforts to describe outcomes after proton therapy across the common pediatric disease sites. We discuss the main attempts to assess comparative efficacy between proton and photon radiotherapy concerning toxicity. We also discuss recent efforts of multi-institutional registries aimed at accelerating research to better define the optimal treatment paradigm for children requiring radiotherapy for cure.
质子放疗有望通过提高对正常组织的保护能力，安全治疗儿科恶性肿瘤，降低急性和迟发性毒性的风险。过去十年，美国已有 30 多家质子设施投入使用，每年为大约 3000 名需要放疗的儿科疾病患儿提供服务的能力有所增加。我们回顾了最初的努力，以描述质子治疗在常见儿科疾病部位的结果。我们讨论了评估质子和光子放疗在毒性方面的相对疗效的主要尝试。我们还讨论了旨在加速研究以更好地确定需要放疗治愈的儿童的最佳治疗模式的多机构登记处的最新进展。
