Çitlenbik Hale, Ulusoy Emel, Er Anıl, Çağlar Aykut, Akgül Fatma, Küme Tuncay, Yılmaz Durgül, Duman Murat
Division of Emergency Care, Department of Pediatrics, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Department of Biochemistry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Pediatr Allergy Immunol Pulmonol. 2019 Sep 1;32(3):121-127. doi: 10.1089/ped.2018.0982. Epub 2019 Sep 17.
Lower respiratory tract infections (LTRIs) are the most common cause of pediatric emergency department visits and are associated with significant morbidity and mortality. The aim of this study was to evaluate the soluble urokinase plasminogen activator receptor (suPAR) levels in pediatric patients with LRTIs and to investigate the correlation of suPAR with disease severity. This is a prospective case-control study of children with LTRIs. Demographic data, diagnoses, vital signs, disease severity scores, length of hospital stay, laboratory findings, and viral polymerase chain reaction results for nasopharyngeal aspirates were recorded. Blood samples for suPAR were collected and assessed by enzyme-linked immunosorbent assay. There were 94 patients with LTRIs and 32 children in the control group. Patients were further subdivided into 2 groups based on diagnosis of acute bronchiolitis (: 31, 33%) or pneumonia (: 63, 67%). The median levels of suPAR were significantly higher in patients with LTRIs than in healthy controls (4.3 and 3.5 ng/mL, respectively; = 0.003). There was an association between suPAR levels and disease severity in pneumonia patients. suPAR values were higher in patients with severe pneumonia than mild pneumonia (5.5 and 3.6 ng/mL, respectively; < 0.001). We have shown that suPAR levels increased in patients with LTRIs and suPAR values were higher in patients with severe pneumonia than mild pneumonia. Further studies with large case series are needed to clarify the role of suPAR levels in children with LTRIs.
下呼吸道感染（LTRIs）是儿科急诊就诊的最常见原因，且与显著的发病率和死亡率相关。本研究的目的是评估LTRIs患儿的可溶性尿激酶型纤溶酶原激活物受体（suPAR）水平，并研究suPAR与疾病严重程度的相关性。这是一项关于LTRIs患儿的前瞻性病例对照研究。记录了人口统计学数据、诊断结果、生命体征、疾病严重程度评分、住院时间、实验室检查结果以及鼻咽抽吸物的病毒聚合酶链反应结果。采集用于检测suPAR的血样，并通过酶联免疫吸附测定法进行评估。LTRIs组有94例患者，对照组有32名儿童。根据急性细支气管炎（n = 31，33%）或肺炎（n = 63，67%）的诊断将患者进一步分为两组。LTRIs患者的suPAR中位数水平显著高于健康对照组（分别为4.3和3.5 ng/mL；P = 0.003）。肺炎患者的suPAR水平与疾病严重程度之间存在关联。重度肺炎患者的suPAR值高于轻度肺炎患者（分别为5.5和3.6 ng/mL；P < 0.001）。我们已经表明，LTRIs患者的suPAR水平升高，且重度肺炎患者的suPAR值高于轻度肺炎患者。需要进一步进行大病例系列研究以阐明suPAR水平在LTRIs患儿中的作用。
