Suwanwongse Kulachanya, Shabarek Nehad
Internal Medicine, Lincoln Medical Center, New York City, USA.
Cureus. 2020 Jan 28;12(1):e6798. doi: 10.7759/cureus.6798.
MicroRNAs (miRNAs) are small, non-protein coding ribonucleic acids (RNAs) that play a critical role in the regulation of gene expression. Change in miRNA expression has been identified in various diseases, including psoriasis. Our narrative review provides an updated overview of current research on miRNA125b and its role in psoriasis pathogenesis. We used the keywords "psoriasis, "microRNA," "miRNA," "miR," and "stRNA" to identify and select studies in PubMed, CINAHL, and Scopus databases from inception to March 2018. The references cited by the retrieved literature were reviewed to broaden our search results. miRNA125b downregulation leads to aberrant proliferation and differentiation of keratinocytes, which is a primary pathology found in psoriasis. Understanding the epigenetic alteration of miRNA125b expression and its underlying molecular mechanisms will help in identifying pathogenesis, diagnosis, and possibly curative treatment of psoriasis in the future.
微小RNA（miRNA）是一类小的、非蛋白质编码核糖核酸（RNA），在基因表达调控中起关键作用。在包括银屑病在内的多种疾病中，已发现miRNA表达发生变化。我们的叙述性综述提供了关于miRNA125b及其在银屑病发病机制中作用的当前研究的最新概述。我们使用关键词“银屑病”“微小RNA”“miRNA”“miR”和“stRNA”，在PubMed、CINAHL和Scopus数据库中检索并筛选了从建库至2018年3月的研究。对检索文献引用的参考文献进行了审查，以扩大我们的检索结果。miRNA125b的下调导致角质形成细胞异常增殖和分化，这是银屑病的主要病理表现。了解miRNA125b表达的表观遗传改变及其潜在分子机制，将有助于未来识别银屑病的发病机制、诊断方法以及可能的治愈性治疗手段。
