Tilley Matthew A, Hatcher Amanda S, Chantler Paul D, Asano Shinichi
Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, WV, USA.
Division of Exercise Physiology, West Virginia University, Morgantown, WV, USA.
Data Brief. 2020 Feb 15;29:105290. doi: 10.1016/j.dib.2020.105290. eCollection 2020 Apr.
Perivascular adipose tissue (PVAT) is recognized as a paracrine organ that controls vascular function. One of the early data demonstrated PVAT from male Sprague-Dawley rats altered aortic vascular reactivity [1]. Subsequent studies have suggested PVAT mediated vascular reactivity is impaired in a variety of vascular beds with animal models of metabolic syndrome [2]. Findings in these experimental animals are generally reported by only male data. Here we report the new data on the effects of PVAT on the aortic reactivity of female lean zucker rats (LZR) and obese zucker rats (OZR). The data presented here is related to a recent manuscript entitled "Aortic dysfunction in metabolic syndrome mediated by perivascular adipose tissue TNFα- and NOX2-dependent pathway" [3] which demonstrated PVAT from male obese Zucker rats (OZR) impaired endothelial function of aorta which is associated with altered PVAT inflammatory signaling.
血管周围脂肪组织（PVAT）被认为是一种控制血管功能的旁分泌器官。早期的数据之一表明，来自雄性Sprague-Dawley大鼠的PVAT改变了主动脉血管反应性[1]。随后的研究表明，在代谢综合征动物模型的各种血管床中，PVAT介导的血管反应性受损[2]。这些实验动物的研究结果通常仅通过雄性数据报告。在这里，我们报告了关于PVAT对雌性瘦型 Zucker 大鼠（LZR）和肥胖 Zucker 大鼠（OZR）主动脉反应性影响的新数据。此处呈现的数据与最近一篇题为“血管周围脂肪组织TNFα和NOX2依赖性途径介导的代谢综合征中的主动脉功能障碍”的手稿相关[3]，该手稿表明来自雄性肥胖 Zucker 大鼠（OZR）的PVAT损害了主动脉的内皮功能，这与PVAT炎症信号改变有关。
