Pourtalebi Jahromi Leila, Ghazali Mohammad, Ashrafi Hajar, Azadi Amir
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Heliyon. 2020 Feb 28;6(2):e03451. doi: 10.1016/j.heliyon.2020.e03451. eCollection 2020 Feb.
Poly (lactic-co-glycolic acid) has received much academic attention for developing nanotherapeutics and FDA has approved it for several applications. An important parameter that dictates the bioavailability and hence the biological effect of the drug is drug release from its delivering system. This study offers a comparative mathematical analysis of drug release from Poly (lactic-co-glycolic acid)-based nanoparticles to suggest a general model explaining multi-mechanistic release they provide.
Eight release models, zero order, first order, Higuchi, Hixson-Crowell, the square root of mass, the three-second root of mass, Weibull and Korsmeyer-Peppas, as well as the second degree polynomial equation were applied to 60 data sets. The models analysed regarding several types of errors, regression parameters and average Akaike information criterion.
Most of the data sets present the highest R, the lowest overall error and AIC for the Weibull model. Weibull model with the mean AIC = -36.37 and mean OE = 7.24 and the highest NE less than 5, 10, 15 and 20 % in most of the cases best fits the release data from various PLGA-based drug delivery systems that are studied. Weibull model seems to show enough flexibility to describe various release patterns PLGA provides.
聚乳酸-乙醇酸共聚物在开发纳米治疗药物方面受到了诸多学术关注，且美国食品药品监督管理局已批准其用于多种应用。决定药物生物利用度进而影响其生物学效应的一个重要参数是药物从其递送系统中的释放。本研究对基于聚乳酸-乙醇酸共聚物的纳米颗粒的药物释放进行了比较数学分析，以提出一个通用模型来解释它们所提供的多机制释放。
将零级、一级、Higuchi、Hixson-Crowell、质量平方根、质量立方根、Weibull和Korsmeyer-Peppas这八种释放模型以及二次多项式方程应用于60个数据集。对这些模型在几种类型的误差、回归参数和平均赤池信息准则方面进行了分析。
大多数数据集对于Weibull模型呈现出最高的R值、最低的总体误差和AIC值。平均AIC = -36.37且平均OE = 7.24、在大多数情况下最高NE小于5%、10%、15%和20%的Weibull模型最适合所研究的各种基于聚乳酸-乙醇酸共聚物的药物递送系统的释放数据。Weibull模型似乎显示出足够的灵活性来描述聚乳酸-乙醇酸共聚物所提供的各种释放模式。
