Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, 610500, China.
Cell Mol Life Sci. 2020 Sep;77(18):3583-3595. doi: 10.1007/s00018-020-03493-z. Epub 2020 Mar 5.
The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. Since the discovery of SF3b, substantial progress has been made in elucidating its molecular mechanism during splicing. In addition, numerous recent studies indicate that SF3b and its components are engaged in various molecular and cellular events that are beyond the canonical role in splicing. This review summarizes the current knowledge on the SF3b complex and highlights its multiple roles in splicing and beyond.
SF3b 复合物是功能性 U2 小核核糖核蛋白 (snRNP) 的固有组成部分。当 U2 snRNP 进入核前体 mRNA 剪接时，SF3b 在识别分支点序列 (BPS) 以及促进剪接体组装和激活方面发挥着关键作用。自 SF3b 被发现以来，在阐明其剪接过程中的分子机制方面已经取得了重大进展。此外，最近的大量研究表明，SF3b 及其组成部分参与了许多超出剪接经典功能的分子和细胞事件。本文综述了 SF3b 复合物的最新研究进展，强调了其在剪接及其他方面的多种作用。
