Ayalogu E O, Phillipson C E, Preece N, Ioannides C, Parke D V
Biochemistry Department, University of Surrey, Guildford, UK.
Ann Nutr Metab. 1988;32(2):75-82. doi: 10.1159/000177411.
Rat hepatic microsomal mixed-function oxidase activities were not significantly affected by vitamin A deficiency. Similarly cytosolic glutathione S-transferase and glutathione reductase activities as well as total glutathione levels were unaffected by the vitamin A status. Induction of the mixed-function oxidases by 3-methylcholanthrene or phenobarbitone was independent of the vitamin A status. No significant differences in microsomal chemiluminescence, before and following challenge with tertiary butyl hydroperoxide, were evident between the vitamin-A-deficient animals and those maintained on vitamin-A-supplemented diets. The present findings indicate that the protective action of vitamin A against chemical carcinogens is unlikely to involve modulation of the enzyme systems responsible for their metabolism.
维生素A缺乏对大鼠肝微粒体混合功能氧化酶活性没有显著影响。同样，胞质谷胱甘肽S-转移酶和谷胱甘肽还原酶活性以及总谷胱甘肽水平也不受维生素A状态的影响。3-甲基胆蒽或苯巴比妥对混合功能氧化酶的诱导与维生素A状态无关。在维生素A缺乏的动物和补充维生素A饮食的动物之间，用叔丁基过氧化氢攻击前后微粒体化学发光没有显著差异。目前的研究结果表明，维生素A对化学致癌物的保护作用不太可能涉及对负责其代谢的酶系统的调节。
