Department of Pulmonary Diseases, School of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
Department of Pulmonary Diseases, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.
Clin Respir J. 2020 Jul;14(7):652-658. doi: 10.1111/crj.13180. Epub 2020 Mar 16.
Obstructive sleep apnea (OSA) is an oxidative stress disease, which has been considered to be a notable risk and associated with increased cardiovascular morbidity and mortality. Thiol-disulfide homeostasis is as a novel indicator of oxidative stress.
We aimed to evaluate thiol-disulfide homeostasis in a large patient population with OSA.
A total of 230 with OSA and 40 healthy controls were included in the study. Inclusion criteria for OSA patients are having apnoea-hypopnoea index of ≥5/hour, being more than 18 years of age and having no previous treatment for OSA. Thiol-disulfide analysis was done for the patients and control group. Blood thiol-disulfide homeostasis was analysed using the new automatic method, developed by Erel and Neşelioğlu.
Among all OSA subjects, 149 (64.8%) were males and the mean ages of the patients were 53.38 ± 10.22. Total thiol, native thiol (SH) and disulfide (SS) levels were significantly lower in OSA group compared to the control group (P < .001, P < .001 and P = .039 respectively). Also, total thiol and native thiol (SH) were significantly different between the groups according to OSA severity (mild-moderate to severe OSA) (P < .001 and P < .001 respectively). Thiol-disulfide redox parameters were correlated with apnoea-hypopnoea index (AHI) scores.
The present prospective study showed that thiol/disulfide homeostasis was unbalanced in OSA patients. Especially, in OSA patients have low level of thiol/disulfide redox parameters when compared to healthy subjects. Evaluating thiol-disulfide homeostasis in OSA may be a contributing aspect to assessment and monitoring of the patient.
阻塞性睡眠呼吸暂停（OSA）是一种氧化应激疾病，已被认为是一个显著的风险因素，并与增加的心血管发病率和死亡率相关。硫醇-二硫化物平衡是氧化应激的一个新指标。
我们旨在评估患有 OSA 的大量患者人群中的硫醇-二硫化物平衡。
共纳入 230 例 OSA 患者和 40 例健康对照者。OSA 患者的纳入标准为每小时呼吸暂停-低通气指数≥5，年龄大于 18 岁，且无 OSA 既往治疗。对患者和对照组进行硫醇-二硫化物分析。采用 Erel 和 Neşelioğlu 开发的新自动方法分析血液硫醇-二硫化物平衡。
所有 OSA 患者中，149 例（64.8%）为男性，患者的平均年龄为 53.38±10.22 岁。与对照组相比，OSA 组的总硫醇、天然硫醇（SH）和二硫化物（SS）水平显著降低（P<0.001、P<0.001 和 P=0.039 分别）。此外，根据 OSA 严重程度（轻度-中度至重度 OSA），总硫醇和天然硫醇（SH）在两组之间也有显著差异（P<0.001 和 P<0.001 分别）。硫醇-二硫化物氧化还原参数与呼吸暂停-低通气指数（AHI）评分相关。
本前瞻性研究表明，OSA 患者的硫醇/二硫化物平衡失衡。特别是，与健康受试者相比，OSA 患者的硫醇/二硫化物氧化还原参数水平较低。评估 OSA 患者的硫醇-二硫化物平衡可能是评估和监测患者的一个贡献方面。
