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动态巯基/二硫键平衡作为糖尿病酮症酸中毒的氧化应激标志物。

Dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis.

机构信息

Department of Emergency Medicine, Ankara City Hospital, Ankara, Turkey

Department of Emergency Medicine, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey

出版信息

Turk J Med Sci. 2021 Apr 30;51(2):743-748. doi: 10.3906/sag-1904-55.

DOI:10.3906/sag-1904-55
PMID:33356023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8203137/
Abstract

BACKGROUND/AIM: The aim of present study was to investigate the dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis (DKA). MATERIALS AND METHODS: A total of 77 participants consisting of 32 patients with DKA and 45 healthy volunteers were included in the study. Thiol/disulfide homeostasis (TDH) [total thiol-native thiol/disulfide changes] were measured in both groups (patient group and control group) using a brand new method developed by Erel and Neselioglu. Half of the difference between total thiol and native thiol concentrations gives the amount of disulfide bond. RESULTS: Total thiol, native thiol, and disulfide levels in blood were found to be low. The levels of total thiol (P < 0.001) and native thiol (P < 0.001 ) were significantly lower in patients with DKA than in the control group. At the same time, the level of disulfide was nonsignificantly lower in the patient group than the control group (P = 0.388). The level of IMA was higher in the patient group than in the control group (P < 0.001). CONCLUSION: The total thiol, native thiol, and disulfide levels in DKA decrease in favor of oxidative stress.

摘要

背景/目的：本研究旨在探讨糖尿病酮症酸中毒（DKA）患者氧化应激标志物——巯基/二硫键动态平衡的变化。

材料和方法：本研究共纳入 77 名参与者，包括 32 名 DKA 患者和 45 名健康志愿者。使用 Erel 和 Neselioglu 开发的全新方法，分别测量两组（患者组和对照组）的巯基/二硫键动态平衡（TDH）[总巯基-天然巯基/二硫键变化]。总巯基和天然巯基浓度之间的一半差异给出二硫键的数量。

结果：血液中的总巯基、天然巯基和二硫化物水平较低。与对照组相比，DKA 患者的总巯基（P<0.001）和天然巯基（P<0.001）水平显著降低。与此同时，患者组中二硫键的水平与对照组相比无显著差异（P=0.388）。与对照组相比，患者组的 IMA 水平更高（P<0.001）。

结论：DKA 患者的总巯基、天然巯基和二硫键水平下降，有利于氧化应激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc4/8203137/12ace2e8fe90/turkjmedsci-51-743-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc4/8203137/d4f75b455765/turkjmedsci-51-743-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc4/8203137/12ace2e8fe90/turkjmedsci-51-743-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc4/8203137/d4f75b455765/turkjmedsci-51-743-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc4/8203137/12ace2e8fe90/turkjmedsci-51-743-fig002.jpg

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Dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis.

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本文引用的文献

[1]
Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects.

Turk J Med Sci. 2020-11-3

[2]
The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters.

Ulus Travma Acil Cerrahi Derg. 2020-1

[3]
Thiol/disulfide homeostasis and ischemia modified albumin levels in autoimmune gastritis and their relations with gastric emptying.

Turk J Med Sci. 2020-2-13

[4]
New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis.

Redox Biol. 2018-10-19

[5]
Effects of Hemodialysis on Thiol-Disulphide Homeostasis in Critically Ill Pediatric Patients with Acute Kidney Injury.

Biomed Res Int. 2018-9-25

[6]
Advanced oxidation protein products and serum total oxidant/antioxidant status levels in rosacea.

Postepy Dermatol Alergol. 2018-6

[7]
The effect of tinea versicolor on thiol/disulphide homeostasis.

Postepy Dermatol Alergol. 2018-6

[8]
Dynamic thiol/disulphide homeostasis in acute pancreatitis.

Turk J Gastroenterol. 2018-5

[9]
The Effect of the 50 g Glucose Challenge Test on The Thiol/Disulfide Homeostasis in Pregnancy.

Fetal Pediatr Pathol. 2018-6

[10]
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.

Antioxid Redox Signal. 2017-4-1

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