State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.
Mol Cell. 2020 Mar 5;77(5):930-931. doi: 10.1016/j.molcel.2020.02.013.
Okazaki and colleagues report that PD-1 signaling mainly restrains effector function at the early stage of T cell activation. The authors find that cytokine genes require strong antigen stimulation and are more susceptible to PD-1 inhibition.
冈崎等人报告称，PD-1 信号主要在 T 细胞激活的早期抑制效应功能。作者发现细胞因子基因需要强烈的抗原刺激，并且更容易受到 PD-1 抑制的影响。
