Helmholtz Zentrum München - German Research Center for Environmental Health, Research Unit Analytical BioGeoChemistry, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.
Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia.
Sci Total Environ. 2020 Jun 10;720:137575. doi: 10.1016/j.scitotenv.2020.137575. Epub 2020 Feb 25.
Chronic exposure to high inorganic As levels in drinking water has been related to many diseases, including type 2 diabetes mellitus (T2D). The association with low and moderate As levels, however, remains controversial and has yet not been studied in European populations. This study aimed to investigate possible association between As exposure and biomarkers of T2D in Croatian population. Observation recruited 86 adults from Eastern Croatia, where groundwater is contaminated with inorganic As, and 116 adults from Western Croatia, where As levels in drinking water are low. Both populations were divided in patient groups (T2D or prediabetes) and healthy controls. Exposure was assessed by determining total As in blood and urine and As metabolites in urine. Eastern Croatian population had a significantly higher content of As in urine than Western, whereas the opposite was true for arsenobetain. Total As and As metabolites in urine positively correlated with hemoglobin A1c (HbA1c) and negatively with albuminuria. This study provides important preliminary data on the levels of As in urine and blood and their association with biomarkers of T2D in Croatian population exposed to low or moderate levels of As through drinking water as a solid basis for further research of the pathophysiological effects of such As exposure on the status and complications of diabetes.
慢性暴露于高浓度无机砷饮用水中与许多疾病有关，包括 2 型糖尿病（T2D）。然而，与低浓度和中等浓度砷的关联仍存在争议，并且尚未在欧洲人群中进行研究。本研究旨在调查克罗地亚人群中砷暴露与 T2D 生物标志物之间可能存在的关联。观察招募了来自克罗地亚东部的 86 名成年人，他们的地下水受到无机砷的污染，以及来自克罗地亚西部的 116 名成年人，他们的饮用水中砷含量较低。这两个群体都分为患者组（T2D 或前驱糖尿病）和健康对照组。通过测定血液和尿液中的总砷和尿液中的砷代谢物来评估暴露情况。与西部人群相比，东部克罗地亚人群尿液中的砷含量明显更高，而砷甜菜碱则相反。尿液中的总砷和砷代谢物与血红蛋白 A1c（HbA1c）呈正相关，与蛋白尿呈负相关。本研究提供了重要的初步数据，表明克罗地亚人群暴露于低浓度或中等浓度砷通过饮用水摄入，其尿液和血液中的砷水平及其与 T2D 生物标志物的关联，为进一步研究这种砷暴露对糖尿病状况和并发症的病理生理影响提供了坚实的基础。
