Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 61469, South Korea.
Department of Ophthalmology, Yanbian University Hospital, Yanji, Jilin, China.
BMC Ophthalmol. 2020 Mar 6;20(1):93. doi: 10.1186/s12886-020-01362-8.
To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes.
The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch's membrane (PPA and PPA, respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA.
An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA width and macular intraretinal layer thickness. Moreover, both PPA and PPA widths significantly correlated with subfoveal choroidal thickness.
Macular intraretinal layer thickness may be affected by PPA width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.
探讨轴向伸长是否会影响黄斑结构，并确定近视眼中黄斑视网膜内厚度与β区神经纤维层旁视网膜萎缩（PPA）微观结构之间的关系。
本研究招募了 113 名健康近视受试者（113 只眼）。使用频域光学相干断层扫描（SD-OCT）获取黄斑、中心凹下脉络膜和视盘的图像。采用自动分割算法将黄斑图像分割为 7 个视网膜内部分层。评估有无布鲁赫膜（PPA 和 PPA）的 PPA 宽度。采用线性回归分析评估黄斑视网膜内厚度与眼轴长度以及 PPA 微观结构之间的关系。
眼轴长度的增加与周边区域全黄斑厚度的减少和中心区域全黄斑厚度的增加相关。黄斑视网膜内各层的厚度变化在周边区域最为明显。PPA 宽度与黄斑视网膜内各层厚度之间存在显著相关性，而 PPA 宽度与黄斑视网膜内各层厚度之间无显著相关性。此外，PPA 和 PPA 宽度均与中心凹下脉络膜厚度显著相关。
黄斑视网膜内各层厚度可能受 PPA 宽度的影响。这些发现表明，在评估近视和青光眼患者的黄斑时，应考虑 PPA 的微观结构。
