Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, Korea.
Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, 25440, Republic of Korea.
Sci Rep. 2020 Mar 6;10(1):4268. doi: 10.1038/s41598-020-61153-5.
Evidence of the association between anemia and risk of PD (Parkinson's disease) have been accumulating. This study aimed to examine the relationship between anemia and risk of PD in Korean older adults. Korean adults aged 50 years or older who participated in the Korean National Screening Program (n = 12,342,278) between 2009 and 2013 were followed until 2015. Cox proportional hazards regression models were used to calculate the hazard ratio (HR) of PD, and participants were followed for a mean period of 5.0 years. At the end of follow-up, 3,844 adults were diagnosed with PD. After adjusting for potential confounders, participants with anemia had decreased risk of PD compared to adults without anemia (adjusted HR (aHR) 0.894, 95% CI: 0.809-0.989). Furthermore, aHR of PD was 0.698 (95% CI: 0.546-0.891) in moderate to severe anemia and 0.938 (95% CI: 0.843-1.044) in mild anemia. The protective effect of anemia was also more profound in men (aHR 0.888, 95% CI: 0.774-1.02) than in women (aHR 0.905, 95% CI: 0.782-1.048). In conclusion, anemia was associated with lower risk of PD, particularly for patients with moderate to severe anemia. Our study suggests that further studies may be needed to clarify the relationship between anemia and PD.
贫血与帕金森病（PD）风险之间的关联证据逐渐增加。本研究旨在检验韩国老年人中贫血与 PD 风险之间的关系。2009 年至 2013 年间，韩国国家筛查计划（n=12342278）招募了 50 岁及以上的韩国成年人，参与者在该计划中接受了随访，直至 2015 年。采用 Cox 比例风险回归模型计算 PD 的风险比（HR），参与者的平均随访时间为 5.0 年。随访结束时，有 3844 名成年人被诊断为 PD。在调整潜在混杂因素后，与无贫血的成年人相比，贫血患者患 PD 的风险降低（调整后的 HR（aHR）为 0.894，95%CI：0.809-0.989）。此外，中重度贫血患者的 PD aHR 为 0.698（95%CI：0.546-0.891），轻度贫血患者的 PD aHR 为 0.938（95%CI：0.843-1.044）。贫血对男性（aHR 0.888，95%CI：0.774-1.02）的保护作用也比女性（aHR 0.905，95%CI：0.782-1.048）更为显著。总之，贫血与 PD 风险降低相关，尤其是中重度贫血患者。我们的研究表明，可能需要进一步研究来阐明贫血与 PD 之间的关系。
