Pringsheim Tamara, Jette Nathalie, Frolkis Alexandra, Steeves Thomas D L
Department of Clinical Neurosciences, University of Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Alberta, Canada.
Mov Disord. 2014 Nov;29(13):1583-90. doi: 10.1002/mds.25945. Epub 2014 Jun 28.
Parkinson's Disease (PD) is a common neurodegenerative disorder. We sought to synthesize studies on the prevalence of PD to obtain an overall view of how the prevalence of this disease varies by age, by sex, and by geographic location. We searched MEDLINE and EMBASE for epidemiological studies of PD from 1985 to 2010. Data were analyzed by age group, geographic location, and sex. Geographic location was stratified by the following groups: 1) Asia, 2) Africa, 3) South America, and 4) Europe/North America/Australia. Meta-regression was used to determine whether a significant difference was present between groups. Forty-seven studies were included in the analysis. Meta-analysis of the worldwide data showed a rising prevalence of PD with age (all per 100,000): 41 in 40 to 49 years; 107 in 50 to 59 years; 173 in 55 to 64 years; 428 in 60 to 69 years; 425 in 65 to 74 years; 1087 in 70 to 79 years; and 1903 in older than age 80. A significant difference was seen in prevalence by geographic location only for individuals 70 to 79 years old, with a prevalence of 1,601 in individuals from North America, Europe, and Australia, compared with 646 in individuals from Asia (P < 0.05). A significant difference in prevalence by sex was found only for individuals 50 to 59 years old, with a prevalence of 41 in females and 134 in males (P < 0.05). PD prevalence increases steadily with age. Some differences in prevalence by geographic location and sex can be detected.
帕金森病（PD）是一种常见的神经退行性疾病。我们试图综合有关PD患病率的研究，以全面了解该疾病的患病率如何随年龄、性别和地理位置而变化。我们在MEDLINE和EMBASE中检索了1985年至2010年期间关于PD的流行病学研究。数据按年龄组、地理位置和性别进行分析。地理位置分为以下几组：1）亚洲，2）非洲，3）南美洲，4）欧洲/北美/澳大利亚。采用Meta回归分析确定各组之间是否存在显著差异。47项研究纳入了分析。全球数据的Meta分析显示，PD患病率随年龄增长而上升（每10万人中的患病率）：40至49岁为41；50至59岁为107；55至64岁为173；60至69岁为428；65至74岁为425；70至79岁为1087；80岁以上为1903。仅在70至79岁的个体中，地理位置对患病率有显著影响，来自北美、欧洲和澳大利亚的个体患病率为1601，而来自亚洲的个体患病率为646（P<0.05）。仅在50至59岁的个体中发现性别对患病率有显著差异，女性患病率为41，男性患病率为134（P<0.05）。PD患病率随年龄稳步上升。在患病率方面可检测到地理位置和性别的一些差异。
