Oepen G, Bork A, Jakovlev V, Nickel B, Thiemer K, Engel J
Forschung der Asta Pharma AG, Frankfurt/Main.
Arzneimittelforschung. 1988 Nov;38(11):1549-52.
Synthesis and pharmacodynamic properties of new analgesic active N'-acylated phenylpiperazines are described. 1-(3-Cyclohexyl-1-oxo-propyl)-4-(2-ethoxyphenyl)-piperazine (D 16 120) possesses strong non-opiate antinociceptive activity showing high therapeutic margin with respect to undesired side effects and toxicity.
