Ciplea A G, Richter K D
Gerhard-Domagk-Institute for Pathology, University of Münster, Fed. Rep. of Germany.
Arzneimittelforschung. 1988 Nov;38(11):1583-92.
Possible protective effects of Allium sativum and Crataegus--alone and in combination--on isoprenaline (isoproterenol)-induced heart, liver and pancreas damage were studied using rats as test animals. Pretreatment with Allium sativum alone, or in combination with Crataegus, resulted in protective effects on isoprenaline-induced damage of heart, liver, and pancreas. These effects proved to be dose-dependent. The following parameters were used to evaluate the protective effect: Clinical signs, qualitative histological and histoenzymatical findings, as well as quantitative microphotometric determination of enzymatic activities of succinate dehydrogenase, NADH-NBT reductase, acid phosphatase and glucose-6-phosphate dehydrogenase in cardiac, hepatic and pancreatic tissues. The underlying mechanisms are discussed. The results suggest that Allium sativum, resp. Allium sativum plus Crataegus exert a pronounced protective effect.
以大鼠为实验动物，研究了大蒜和山楂单独及联合使用对异丙肾上腺素诱导的心脏、肝脏和胰腺损伤的可能保护作用。单独使用大蒜或与山楂联合预处理，对异丙肾上腺素诱导的心脏、肝脏和胰腺损伤均有保护作用。这些作用呈剂量依赖性。采用以下参数评估保护作用：临床症状、定性组织学和组织酶学结果，以及心脏、肝脏和胰腺组织中琥珀酸脱氢酶、NADH-NBT还原酶、酸性磷酸酶和葡萄糖-6-磷酸脱氢酶活性的定量显微光度测定。并对潜在机制进行了讨论。结果表明，大蒜，或大蒜加山楂具有显著的保护作用。
