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欧洲核医学协会剂量测定委员会关于碘-间位碘代苄胍（I mIBG）治疗神经内分泌肿瘤内照射剂量测定标准操作程序的系列文章

EANM Dosimetry Committee series on standard operational procedures for internal dosimetry for I mIBG treatment of neuroendocrine tumours.

作者信息

Gear Jonathan, Chiesa Carlo, Lassmann Michael, Gabiña Pablo Mínguez, Tran-Gia Johannes, Stokke Caroline, Flux Glenn

机构信息

Joint Department of Physics, Royal Marsden Hospital & Institute of Cancer Research, Sutton, UK.

Nuclear Medicine, Foundation IRCCS Istituto Nazionale Tumori, Milan, Italy.

出版信息

EJNMMI Phys. 2020 Mar 6;7(1):15. doi: 10.1186/s40658-020-0282-7.

DOI:10.1186/s40658-020-0282-7
PMID:32144574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7060302/
Abstract

The purpose of the EANM Dosimetry Committee Series on "Standard Operational Procedures for Dosimetry" (SOP) is to provide advice to scientists and clinicians on how to perform patient-specific absorbed dose assessments. This SOP describes image and data acquisition parameters and dosimetry calculations to determine the absorbed doses delivered to whole-body, tumour and normal organs following a therapeutic administration of I mIBG for the treatment of neuroblastoma or adult neuroendocrine tumours. Recommendations are based on evidence in recent literature where available and on expert opinion within the community. This SOP is intended to promote standardisation of practice within the community and as such is based on the facilities and expertise that should be available to any centre able to perform specialised treatments with radiopharmaceuticals and patient-specific dosimetry. A clinical example is given to demonstrate the application of the absorbed dose calculations.

摘要

欧洲核医学协会剂量测定委员会关于“剂量测定标准操作程序”（SOP）系列的目的是就如何进行患者特异性吸收剂量评估向科学家和临床医生提供建议。本SOP描述了图像和数据采集参数以及剂量测定计算方法，以确定在使用131I-间碘苄胍（131I-mIBG）治疗神经母细胞瘤或成人神经内分泌肿瘤后，全身、肿瘤和正常器官所接受的吸收剂量。建议基于现有最新文献中的证据以及该领域的专家意见。本SOP旨在促进该领域内实践的标准化，因此是基于任何能够使用放射性药物进行特殊治疗和患者特异性剂量测定的中心应具备的设施和专业知识制定的。文中给出了一个临床实例以展示吸收剂量计算的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/4be081e7d0e8/40658_2020_282_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/f030385b54c2/40658_2020_282_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/1e6d3b88a6eb/40658_2020_282_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/09834b9fa38f/40658_2020_282_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/4be081e7d0e8/40658_2020_282_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/f030385b54c2/40658_2020_282_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/1e6d3b88a6eb/40658_2020_282_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/09834b9fa38f/40658_2020_282_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2148/7060302/4be081e7d0e8/40658_2020_282_Fig4_HTML.jpg

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