• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用样条重建技术对小鼠心肌葡萄糖代谢进行无创定量分析。

Noninvasive Quantification of Glucose Metabolism in Mice Myocardium Using the Spline Reconstruction Technique.

作者信息

Vrachliotis Alexandros, Gaitanis Anastasios, Protonotarios Nicholas E, Kastis George A, Costaridou Lena

机构信息

Department of Medical Physics, School of Medicine, University of Patras, 26504 Patras, Greece.

Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation (BRFAA), Academy of Athens, 4 Soranou Ephessiou, 11527 Athens, Greece.

出版信息

J Imaging. 2024 Jul 16;10(7):170. doi: 10.3390/jimaging10070170.

DOI:10.3390/jimaging10070170
PMID:39057741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11278115/
Abstract

The spline reconstruction technique (SRT) is a fast algorithm based on a novel numerical implementation of an analytic representation of the inverse Radon transform. The purpose of this study was to compare the SRT, filtered back-projection (FBP), and the Tera-Tomo 3D algorithm for various iteration numbers, using small-animal dynamic PET data obtained from a Mediso nanoScan PET/CT scanner. For this purpose, Patlak graphical kinetic analysis was employed to noninvasively quantify the myocardial metabolic rate of glucose (MRGlu) in seven male C57BL/6 mice (n=7). All analytic reconstructions were performed via software for tomographic image reconstruction. The analysis of all PET-reconstructed images was conducted with PMOD software (version 3.506, PMOD Technologies LLC, Fällanden, Switzerland) using the inferior vena cava as the image-derived input function. Statistical significance was determined by employing the one-way analysis of variance test. The results revealed that the differences between the values of MRGlu obtained via SRT versus FBP, and the variants of he Tera-Tomo 3D algorithm were not statistically significant ( > 0.05). Overall, the SRT appears to perform similarly to the other algorithms investigated, providing a valid alternative analytic method for preclinical dynamic PET studies.

摘要

样条重建技术（SRT）是一种基于逆拉东变换解析表示的新型数值实现的快速算法。本研究的目的是使用从Mediso nanoScan PET/CT扫描仪获得的小动物动态PET数据，比较不同迭代次数下的SRT、滤波反投影（FBP）和Tera-Tomo 3D算法。为此，采用Patlak图形动力学分析对7只雄性C57BL/6小鼠（n = 7）的心肌葡萄糖代谢率（MRGlu）进行无创定量。所有解析重建均通过断层图像重建软件进行。使用下腔静脉作为图像衍生输入函数，使用PMOD软件（版本3.506，PMOD Technologies LLC，瑞士费伦登）对所有PET重建图像进行分析。采用单因素方差分析检验确定统计学意义。结果显示，通过SRT与FBP以及Tera-Tomo 3D算法变体获得的MRGlu值之间的差异无统计学意义（> 0.05）。总体而言，SRT的表现似乎与所研究的其他算法相似，为临床前动态PET研究提供了一种有效的替代解析方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/7c9cf1f988ed/jimaging-10-00170-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/8669cb337574/jimaging-10-00170-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/6e01b686a2bb/jimaging-10-00170-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/c3f582763667/jimaging-10-00170-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/57d92142bc18/jimaging-10-00170-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/e62ad8278b9b/jimaging-10-00170-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/7c9cf1f988ed/jimaging-10-00170-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/8669cb337574/jimaging-10-00170-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/6e01b686a2bb/jimaging-10-00170-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/c3f582763667/jimaging-10-00170-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/57d92142bc18/jimaging-10-00170-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/e62ad8278b9b/jimaging-10-00170-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ed/11278115/7c9cf1f988ed/jimaging-10-00170-g006.jpg

相似文献

1
Noninvasive Quantification of Glucose Metabolism in Mice Myocardium Using the Spline Reconstruction Technique.使用样条重建技术对小鼠心肌葡萄糖代谢进行无创定量分析。
J Imaging. 2024 Jul 16;10(7):170. doi: 10.3390/jimaging10070170.
2
Evaluation of the spline reconstruction technique for preclinical PET imaging.临床前 PET 成像中样条重建技术的评估。
Comput Methods Programs Biomed. 2022 Apr;217:106668. doi: 10.1016/j.cmpb.2022.106668. Epub 2022 Feb 1.
3
Evaluation of the spline reconstruction technique for PET.正电子发射断层显像（PET）的样条重建技术评估
Med Phys. 2014 Apr;41(4):042501. doi: 10.1118/1.4867862.
4
The SRT reconstruction algorithm for semiquantification in PET imaging.PET成像中用于半定量分析的SRT重建算法。
Med Phys. 2015 Oct;42(10):5970-82. doi: 10.1118/1.4931409.
5
Investigation of Image Reconstruction Parameters of the Mediso nanoScan PC Small-Animal PET/CT Scanner for Two Different Positron Emitters Under NEMA NU 4-2008 Standards.在NEMA NU 4-2008标准下，对Mediso nanoScan PC小动物PET/CT扫描仪针对两种不同正电子发射体的图像重建参数进行研究。
Mol Imaging Biol. 2017 Aug;19(4):550-559. doi: 10.1007/s11307-016-1035-9.
6
Evaluation of the Small-animal Nano Scan PET/CT System using Zr.采用 Zr 对小动物 Nano Scan PET/CT 系统进行评估
Curr Med Imaging. 2021;17(2):296-305. doi: 10.2174/1573405616666201012154548.
7
Impact of Image-Derived Input Function and Fit Time Intervals on Patlak Quantification of Myocardial Glucose Uptake in Mice.图像衍生输入函数和拟合时间间隔对小鼠心肌葡萄糖摄取的Patlak定量分析的影响
J Nucl Med. 2015 Oct;56(10):1615-21. doi: 10.2967/jnumed.115.160820. Epub 2015 Aug 13.
8
Experimental and clinical evaluation of iterative reconstruction (OSEM) in dynamic PET: quantitative characteristics and effects on kinetic modeling.动态正电子发射断层扫描中迭代重建（有序子集期望最大化算法）的实验与临床评估：定量特征及其对动力学建模的影响
J Nucl Med. 2001 May;42(5):808-17.
9
Quantitative comparison of analytic and iterative reconstruction methods in 2- and 3-dimensional dynamic cardiac 18F-FDG PET.二维和三维动态心脏18F-FDG PET中解析重建方法与迭代重建方法的定量比较
J Nucl Med. 2004 Dec;45(12):2008-15.
10
Ultra-low peak voltage CT colonography: effect of iterative reconstruction algorithms on performance of radiologists who use anthropomorphic colonic phantoms.超低峰值电压 CT 结肠成像：迭代重建算法对使用人体结肠模型的放射科医生性能的影响。
Radiology. 2014 Dec;273(3):759-71. doi: 10.1148/radiol.14140192. Epub 2014 Jul 11.

本文引用的文献

1
Evaluation of the spline reconstruction technique for preclinical PET imaging.临床前 PET 成像中样条重建技术的评估。
Comput Methods Programs Biomed. 2022 Apr;217:106668. doi: 10.1016/j.cmpb.2022.106668. Epub 2022 Feb 1.
2
Estimation of the net influx rate K and the cerebral metabolic rate of glucose MR using a single static [F]FDG PET scan in rats.使用大鼠单次静态 [F]FDG PET 扫描估计净流入率 K 和脑葡萄糖代谢率 MR。
Neuroimage. 2021 Jun;233:117961. doi: 10.1016/j.neuroimage.2021.117961. Epub 2021 Mar 17.
3
FBP-Net for direct reconstruction of dynamic PET images.
FBP-Net 用于动态 PET 图像的直接重建。
Phys Med Biol. 2020 Nov 20;65(23). doi: 10.1088/1361-6560/abc09d.
4
Kinetic modeling and parametric imaging with dynamic PET for oncological applications: general considerations, current clinical applications, and future perspectives.动力学建模和动态 PET 参数成像在肿瘤学中的应用：一般考虑、当前临床应用和未来展望。
Eur J Nucl Med Mol Imaging. 2021 Jan;48(1):21-39. doi: 10.1007/s00259-020-04843-6. Epub 2020 May 19.
5
Recent advances of PET imaging in clinical radiation oncology.正电子发射断层扫描成像在临床放射肿瘤学中的新进展。
Radiat Oncol. 2020 Apr 21;15(1):88. doi: 10.1186/s13014-020-01519-1.
6
PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers.正电子发射断层扫描（PET）成像显示，在健康人类志愿者中，干扰素-α免疫挑战后 TSPO 脑密度没有变化。
Transl Psychiatry. 2020 Mar 9;10(1):89. doi: 10.1038/s41398-020-0768-z.
7
EANM Dosimetry Committee series on standard operational procedures for internal dosimetry for I mIBG treatment of neuroendocrine tumours.欧洲核医学协会剂量测定委员会关于碘-间位碘代苄胍（I mIBG）治疗神经内分泌肿瘤内照射剂量测定标准操作程序的系列文章
EJNMMI Phys. 2020 Mar 6;7(1):15. doi: 10.1186/s40658-020-0282-7.
8
FDG PET/CT of COVID-19.新型冠状病毒肺炎的氟代脱氧葡萄糖正电子发射断层显像/X线计算机体层成像（FDG PET/CT）
Radiology. 2020 Aug;296(2):E118. doi: 10.1148/radiol.2020200770. Epub 2020 Mar 6.
9
Image-Derived Input Functions for Quantification of A Adenosine Receptors Availability in Mice Brains Using PET and [F]CPFPX.使用PET和[F]CPFPX对小鼠大脑中A腺苷受体可用性进行定量的图像衍生输入函数
Front Physiol. 2020 Jan 29;10:1617. doi: 10.3389/fphys.2019.01617. eCollection 2019.
10
The attenuated spline reconstruction technique for single photon emission computed tomography.衰减样条重建技术在单光子发射计算机断层中的应用。
J R Soc Interface. 2018 Nov 28;15(148):20180509. doi: 10.1098/rsif.2018.0509.