Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Nanakuma 7-45-1, Jonan-ku, Fukuoka, 814-0180, Japan.
Nursing Department, Fukuoka University Hospital, Nanakuma 7-45-1, Jonan-ku, Fukuoka, 814-0180, Japan.
Support Care Cancer. 2020 Nov;28(11):5405-5410. doi: 10.1007/s00520-020-05387-z. Epub 2020 Mar 6.
The incidence and time of onset of acute chemotherapy-induced peripheral neuropathy (ACIPN) caused by oxaliplatin remain unclarified. Hence, we investigated the prevalence, onset time, and location of ACIPN symptoms in patients with colorectal cancer (CRC) receiving oxaliplatin without cold stimulation.
The study cohort comprised patients receiving oxaliplatin for CRC at our hospital between April 2017 and August 2018. Patients were instructed not to touch and/or drink cold things and were monitored for ACIPN symptoms in the hospital for 24 h after chemotherapy. ACIPN symptoms that appeared > 24 h after chemotherapy were recorded at the next visit. Symptom appearance time was defined as the duration from the administration of chemotherapy until the appearance of paresthesia classified as grade 1 using the Common Terminology Criteria for Adverse Events.
Forty-five patients received chemotherapy, comprising 23 men and 22 women, aged 67 years (29-88 years). The location of ACIPN was the fingers in 55.6% of cases, pharynx in 26.7%, perioral region in 24.4%, and feet in 6.7%. The average duration from oxaliplatin administration to symptom development was 182 min (range 62-443 min) for the fingers, 291 min (176-432 min) for the pharynx, 311 min (127-494 min) for the perioral region, and 297 min (234-355 min) for the feet. Pharyngeal symptoms were more common in patients older than 65 years than in those younger than 65 years.
The incidence and time of the onset of ACIPN caused by oxaliplatin varies between the body and regions.
奥沙利铂引起的急性化疗诱导性周围神经病（ACIPN）的发生率和发病时间尚不清楚。因此，我们研究了在我院接受奥沙利铂治疗而未接受冷刺激的结直肠癌（CRC）患者中 ACIPN 症状的发生率、发病时间和部位。
研究队列包括 2017 年 4 月至 2018 年 8 月期间在我院接受奥沙利铂治疗的 CRC 患者。患者被指示不要接触和/或饮用冷物，并在化疗后 24 小时内在医院内监测 ACIPN 症状。化疗后 >24 小时出现的症状在下一次就诊时记录。症状出现时间定义为从给予化疗到出现按照不良事件通用术语标准（Common Terminology Criteria for Adverse Events）分类为 1 级的感觉异常的时间。
45 例患者接受了化疗，其中 23 例为男性，22 例为女性，年龄 67 岁（29-88 岁）。ACIPN 的部位为手指 55.6%，咽部 26.7%，口周 24.4%，足部 6.7%。从奥沙利铂给药到症状出现的平均时间为手指 182 分钟（62-443 分钟），咽部 291 分钟（176-432 分钟），口周 311 分钟（127-494 分钟），足部 297 分钟（234-355 分钟）。65 岁以上患者咽部症状较 65 岁以下患者更常见。
奥沙利铂引起的 ACIPN 的发生率和发病时间在身体和部位之间存在差异。
