Department of Oral Medicine, Hospital Sírio-Libanês, Street Dona Adma Jafet 91-Bela Vista, São Paulo, SP, Brazil.
Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Street Professor Moacir Gomes de Freitas 688, Belo Horizonte, Brazil.
Support Care Cancer. 2020 Nov;28(11):5397-5404. doi: 10.1007/s00520-020-05374-4. Epub 2020 Mar 6.
To assess the current knowledge regarding medication-related osteonecrosis of the jaw (MRONJ); the adverse effects of anti-resorptive (AR) and anti-angiogenic (AA) drugs; strategies for MRONJ prevention and treatment; and perception of the dentist's role in assisting patients who use these drugs among physicians, dentists, and nurses.
Using questionnaires, the current knowledge of MRONJ was assessed among dentists, physicians, and nurses, who were divided into group I, which included specialties that directly assist cancer patients, and group II, which included other specialties. The questionnaires assessed the characteristics of the health professionals, training time, and specialties; their knowledge of AR and AA drugs; and their knowledge of MRONJ.
A total of 1370 health professionals participated in the study, including 1032 dentists, 239 physicians, and 99 nurses. Among dentists and physicians, the training time (p = 0.036 and p < 0.001, respectively) and specialization in group I domains (p < 0.001 and p < 0.001, respectively) had a significant impact on MRONJ knowledge, while nurses showed no significant impact regardless of the training time and specialty. Less than 10% of the physicians and dentists could correlate the signs and symptoms of all stages of MRONJ.
The findings indicated a notable lack of knowledge regarding MRONJ among dental surgeons and physicians, and especially among nurses. More experienced professionals and specialists in the areas that assist cancer patients usually have a greater understanding of the dentist's role in MRONJ prevention, diagnosis, treatment, and patient care and will introduce or are already using AR and AA drugs.
评估目前关于药物相关性颌骨坏死（MRONJ）的知识；抗吸收（AR）和抗血管生成（AA）药物的不良反应；MRONJ 预防和治疗策略；以及牙医在协助使用这些药物的患者方面的作用在医生、牙医和护士中的认知。
使用问卷评估牙医、医生和护士对 MRONJ 的现有知识，他们分为第一组，包括直接协助癌症患者的专业人员，和第二组，包括其他专业人员。问卷评估了卫生专业人员的特征、培训时间和专业领域；他们对 AR 和 AA 药物的了解；以及他们对 MRONJ 的了解。
共有 1370 名卫生专业人员参与了这项研究，包括 1032 名牙医、239 名医生和 99 名护士。在牙医和医生中，培训时间（p=0.036 和 p<0.001）和第一组领域的专业化（p<0.001 和 p<0.001）对 MRONJ 知识有显著影响，而护士无论培训时间和专业领域如何，均无显著影响。不到 10%的医生和牙医能够将 MRONJ 所有阶段的体征和症状联系起来。
研究结果表明，牙医和医生，尤其是护士，对 MRONJ 的了解明显不足。在协助癌症患者的领域经验更丰富的专业人员和专家通常更了解牙医在 MRONJ 预防、诊断、治疗和患者护理方面的作用，并将引入或已经在使用 AR 和 AA 药物。
