Private Practice for Oral and Maxillofacial Surgery, A-5020 Salzburg, Austria.
University Hospital for Craniomaxillofacial and Oral Surgery, Medical University Innsbruck, A-6020 Innsbruck, Austria.
Int J Environ Res Public Health. 2021 Apr 22;18(9):4466. doi: 10.3390/ijerph18094466.
Medication-related osteonecrosis of the jaw (MRONJ) is a side effect of antiresorptive drugs. In this online survey, the awareness and knowledge of dentists regarding MRONJ was evaluated, and potential implications for oncologists are discussed. Questionnaires were emailed to dentists from Germany, Austria, Switzerland, and South Tyrol to evaluate disease-related knowledge and management. In addition to the overall score, a separate score was calculated for knowledge (maximum score: 15 points) and management (maximum score: 6 points) questions, and 1197 valid replies with completed questionnaires were received. The mean overall score was 10.45 ± 3.97 points, the mean knowledge score was 7.68 ± 3.05 points, and the mean management score was 2.76 ± 1.77 points. Factors influencing the outcome of the overall score were age, specialization, continuous professional education, and the number of dental screening exams in patients before antiresorptive therapy. Due to the considerable lack of knowledge regarding MRONJ among dentists, MRONJ patients and subjects at risk should be guided towards specialists for dental screening, treatment, and follow-up. This is important from an oncologic point of view to avoid any delay for treatment start of antiresorptives, and to reveal a potentially emerging osteonecrosis at an early stage, thus, avoiding the need for interruption or even cancellation of antiresorptive therapy.
药物相关性颌骨坏死(MRONJ)是抗吸收药物的一种副作用。在这项在线调查中,评估了牙医对 MRONJ 的认识和知识,讨论了对肿瘤学家的潜在影响。从德国、奥地利、瑞士和南蒂罗尔的牙医那里通过电子邮件发送问卷,以评估与疾病相关的知识和管理。除了总评分外,还为知识(最高得分为 15 分)和管理(最高得分为 6 分)问题计算了单独的评分,共收到 1197 份有效回复和完整的问卷。平均总分为 10.45 ± 3.97 分,平均知识得分为 7.68 ± 3.05 分,平均管理得分为 2.76 ± 1.77 分。影响总体评分结果的因素有年龄、专业化、持续的专业教育以及在抗吸收治疗前对患者进行的牙科筛查检查次数。由于牙医对 MRONJ 的认识相当缺乏,MRONJ 患者和有风险的患者应被引导到专科医生进行牙科筛查、治疗和随访。从肿瘤学的角度来看,这一点很重要,以避免抗吸收药物治疗开始的任何延迟,并及早发现潜在的骨坏死,从而避免中断甚至取消抗吸收治疗的需要。