Zhang Shi Ke, He Hui, Gao Wei Bin, Wu Xiao Ke, Zhang Duo Jia
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
National Prestigious Chinese Medicine Physician Studio, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040.
Zhen Ci Yan Jiu. 2020 Feb 25;45(2):164-8. doi: 10.13702/j.1000-0607.1802616.
Non-invasive transcutaneous auricular vagus nerve stimulation (ta-VNS) is established on the basis of auricular acupuncture and the principle of vagus nerve stimulation (VNS). The results of the comparative study of 4 indications of VNS show that ta-VNS achieves almost the equivalent effect as VNS. Moreover, the ta-VNS is advantageous at safety, economy and portability. Regarding the clinical prevention and treatment of polycystic ovary syndrome (PCOS), it is still controversial for the effect of acupuncture and moxibustion therapy including auricular acupuncture. Moreover, it is the difficulty for the principle of acupoint selection and the treatment mechanism of this therapy to be in line with modern medicine. As neuroendocrine disease, PCOS and the ovary, its target organ are all associated with the vagus nerve. It is a new idea to introduce the ta-VNS in treatment of PCOS by regulating the reproductive and endocrinal disturbance of PCOS in terms of vagus nerve and improving the acupuncture and moxibustion therapy, such as the auricular acupuncture. In the paper, the potential mechanism of the ta-VNS in treatment of PCOS is presented: 1)the ta-VNS treats PCOS by improving insulin resistance; 2)the ta-VNS relieves PCOS-induced psychological disorders through the treatment of depression; 3)the ta-VNS is applicable in treatment of PCOS complications, such as hypertension and diabetes.
非侵入性经皮耳迷走神经刺激（ta-VNS）是在耳针疗法和迷走神经刺激（VNS）原理的基础上建立的。对VNS的4种适应症进行比较研究的结果表明，ta-VNS取得的效果几乎与VNS相当。此外，ta-VNS在安全性、经济性和便携性方面具有优势。关于多囊卵巢综合征（PCOS）的临床防治，包括耳针疗法在内的针灸治疗效果仍存在争议。此外，该疗法的选穴原则和治疗机制与现代医学接轨存在困难。作为神经内分泌疾病，PCOS及其靶器官卵巢均与迷走神经相关。从迷走神经角度调节PCOS的生殖和内分泌紊乱，引入ta-VNS改进针灸疗法如耳针疗法，是治疗PCOS的新思路。本文阐述了ta-VNS治疗PCOS的潜在机制：（1）ta-VNS通过改善胰岛素抵抗治疗PCOS；（2）ta-VNS通过治疗抑郁症缓解PCOS引起的心理障碍；（3）ta-VNS适用于治疗PCOS并发症，如高血压和糖尿病。
