经皮耳迷走神经刺激治疗耐药性癫痫的一种替代疗法。
An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation.
机构信息
Function Laboratory, Institute of Acu-Mox, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
出版信息
Chin Med J (Engl). 2014;127(2):300-4.
BACKGROUND
Previous studies demonstrated that vagus nerve stimulation (VNS) is an effective therapy for drug-resistant epilepsy. Acupuncture is also used to treat epilepsy. This study was designed to examine the safety and effectiveness of transcutaneous auricular vagus nerve stimulation (ta-VNS) for patients with drug-resistant epilepsy.
METHODS
A total of 50 volunteer patients with drug-resistant epilepsy were selected for a random clinical trial to observe the therapeutic effect of ta-VNS. The seizure frequency, quality of life, and severity were assessed in weeks 8, 16, and 24 of the treatment according to the percentage of seizure frequency reduction.
RESULTS
In the pilot study, 47 of the 50 epilepsy patients completed the 24-week treatment; three dropped off. After 8-week treatment, six of the 47 patients (12%) were seizure free and 12 (24%) had a reduction in seizure frequency. In week 16 of the continuous treatment, six of the 47 patients (12%) were seizure free; 17 (34%) had a reduction in seizure frequency. After 24 weeks' treatment, eight patients (16%) were seizure free; 19 (38%) had reduced seizure frequency.
CONCLUSION
Similar to the therapeutic effect of VNS, ta-VNS can suppress epileptic seizures and is a safe, effective, economical, and widely applicable treatment option for drug-resistant epilepsy. (ChiCTR-TRC-10001023).
背景
先前的研究表明，迷走神经刺激（VNS）是治疗耐药性癫痫的有效疗法。针灸也用于治疗癫痫。本研究旨在检查经皮耳迷走神经刺激（ta-VNS）治疗耐药性癫痫患者的安全性和有效性。
方法
共选择 50 名耐药性癫痫志愿者患者进行随机临床试验，以观察 ta-VNS 的治疗效果。根据发作频率减少的百分比，在治疗的第 8、16 和 24 周评估发作频率、生活质量和严重程度。
结果
在初步研究中，50 例癫痫患者中有 47 例完成了 24 周的治疗；3 例脱落。经过 8 周的治疗，47 例患者中有 6 例（12%）无发作，12 例（24%）发作频率降低。在连续治疗的第 16 周，47 例患者中有 6 例（12%）无发作；17 例（34%）发作频率降低。经过 24 周的治疗，8 例患者（16%）无发作；19 例（38%）发作频率降低。
结论
与 VNS 的治疗效果相似，ta-VNS 可以抑制癫痫发作，是一种安全、有效、经济、广泛适用的耐药性癫痫治疗选择。（ChiCTR-TRC-10001023）。
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