Shortall J, Vasquez Osorio E, Aitkenhead A, Berresford J, Agnew J, Budgell G, Chuter R, McWilliam A, Kirkby K, Mackay R, van Herk M
Department of Cancer Sciences, The University of Manchester, Manchester, UK.
Department of Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK.
Med Phys. 2020 Jun;47(6):2506-2515. doi: 10.1002/mp.14123. Epub 2020 Mar 28.
Dose deposition around unplanned air cavities during magnetic resonance-guided radiotherapy (MRgRT) is influenced by the electron return effect (ERE). This is clinically relevant for gas forming close to or inside organs at risk (OARs) that lie in the path of a single beam, for example, intestinal track during pelvic treatment. This work aims to verify Monte Carlo calculations that predict the dosimetric effects of ERE around air cavities. For this, we use GafChromic EBT3 film inside poly-methyl methacrylate (PMMA) -air phantoms.
Four PMMA phantoms were produced. Three of the phantoms contained centrally located spherical air cavities (0.5, 3.5, 7.5 cm diameter), and one phantom contained no air. The phantoms were split to sandwich GafChromic EBT3 film in the center. The phantoms were irradiated on an Elekta Unity system using a single 10 × 10 cm 7-MV photon beam under the influence of a 1.5-T transverse magnetic field. The measurements were replicated using the Elekta Monaco treatment planning system (TPS). Gamma analysis with pass criteria 3%/3 mm was used to compare the measured and calculated dose distributions. We also consider 3%/2 mm, 2%/3 mm, and 2%/2 mm pass criteria for interest.
The gamma analysis showed that >95% of the points agreed between the TPS-calculated and measured dose distributions, using 3%/3 mm criteria. The phantom containing the largest air cavity had the lowest agreement, with most of the disagreeing points lying inside the air cavity (dose to air region).
The dose effects due to ERE around spherical air cavities are being calculated in the TPS with sufficient accuracy for clinical use.
磁共振引导放疗(MRgRT)期间,计划外气腔周围的剂量沉积受电子返回效应(ERE)影响。这在临床方面与位于单束射线路径上的危险器官(OARs)附近或内部形成气体有关,例如盆腔治疗期间的肠道。这项工作旨在验证预测气腔周围ERE剂量学效应的蒙特卡罗计算。为此,我们在聚甲基丙烯酸甲酯(PMMA)-空气体模中使用GafChromic EBT3薄膜。
制作了四个PMMA体模。其中三个体模包含位于中心的球形气腔(直径0.5、3.5、7.5厘米),一个体模没有气腔。将体模劈开,在中间夹入GafChromic EBT3薄膜。在1.5-T横向磁场影响下,使用单个10×10厘米的7-MV光子束在Elekta Unity系统上对体模进行照射。使用Elekta Monaco治疗计划系统(TPS)重复测量。采用3%/3毫米通过率标准的伽马分析来比较测量和计算的剂量分布。我们还考虑了3%/2毫米、2%/3毫米和2%/2毫米通过率标准以供参考。
伽马分析表明,使用3%/3毫米标准时,TPS计算的剂量分布与测量的剂量分布之间>95%的点一致。包含最大气腔的体模一致性最低,大多数不一致点位于气腔内(空气区域剂量)。
TPS中对球形气腔周围ERE引起的剂量效应进行了足够准确的计算,可用于临床。