Brodovskaya T O, Grishina I F, Bazhenova O V, Kovin E A, Peretolchina T F
Ural State Medical University, 3 Repina str., Yekaterinburg 620028, Russian Federation, e-mail:
Adv Gerontol. 2019;32(5):748-757.
The objective was to assess the role of pathological changes in cerebral hemodynamics in obstructive sleep apnea comorbid obesity patients in premature aging. Concentric-eccentric remodeling of the common carotid artery wall, hyperconstrictor variant of cerebral angiopathy, depletion of compensatory mechanisms of cerebral blood flow autoregulation, restriction of hemodynamic reserve with narrowing of the «corridor» of admissible changes in cerebral perfusion in patients with respiratory disturbances comorbid obesity. The biological age of sleep apnea patients exceeded the passport age by 41,3%, and comorbid patients by 49,6%. The most significant predictors of premature aging in both groups are cerebral hemodynamic indicators, reflecting the structural and geometric characteristics of the vessels, in particular, the thickness of the intima-media complex of the common carotid artery, as well as microvasculature reactivity indicators. In comorbid individuals, an additional marker of early aging may be the cerebral blood flow index. Patients with sleep apnea and obesity are characterized by accelerated rates of aging. Indicators of cerebral hemodynamics can be considered as markers of premature aging.
目的是评估阻塞性睡眠呼吸暂停合并肥胖患者脑血流动力学的病理变化在早衰中的作用。颈总动脉壁的向心性 - 离心性重塑、脑血管病的高收缩变体、脑血流自动调节代偿机制的耗竭、呼吸障碍合并肥胖患者脑灌注允许变化的“通道”变窄导致血流动力学储备受限。睡眠呼吸暂停患者的生物学年龄比实际年龄超出41.3%，合并症患者超出49.6%。两组早衰的最显著预测因素是反映血管结构和几何特征的脑血流动力学指标，特别是颈总动脉内膜 - 中膜复合体的厚度，以及微血管反应性指标。在合并症个体中，脑血流指数可能是早衰的另一个标志物。睡眠呼吸暂停和肥胖患者具有加速衰老的特征。脑血流动力学指标可被视为早衰的标志物。
