College of Electronic and Information Engineering, Hebei University, Baoding, China; Research Center of Machine Vision Engineering & Technology of Hebei Province, Baoding, China; Key Laboratory of Digital Medical Engineering of Hebei Province, Baoding, China.
College of Electronic and Information Engineering, Hebei University, Baoding, China.
Neurosci Lett. 2020 Apr 17;724:134891. doi: 10.1016/j.neulet.2020.134891. Epub 2020 Mar 4.
Sex plays an important role in many diseases. The purpose of current study is to explore whether there are different lesion patterns in the RSN functional connections between males and females with MCI progression, and identify the differences in brain network changes due to sex.
Resting state fMRI data included 37 normal controls (NC), 39 early MCI (EMCI) patients and 37 late MCI (LMCI) patients were collected, and network model based on graph theory was performed to compare the differences of brain network at different stages caused by sex from three aspects: functional connectivity between ROIs, intra-functional connectivity within RSN and inter-functional connectivity between RSN and white matter (WM).
Sex plays a role in the changes of RSN functional connectivity, including the default mode network (DMN), the sensory-motor network (SMN), the dorsal attention network (DAN) and the executive control network (CON). The female SMN is more vulnerable and the damage of functional connectivity between DAN and WM is more serious.
There are different lesion patterns in the RSN functional connections between males and females in the progression of MCI, which suggests that we should take full account of sex differences when conducting MCI progress studies and developing more effective biomarkers to promote the progress of cognitive impairment and dementia.
性别在许多疾病中起着重要作用。本研究旨在探讨男性和女性轻度认知障碍（MCI）进展过程中，其默认模式网络（DMN）、感觉运动网络（SMN）、背侧注意网络（DAN）和执行控制网络（CON）等静息态网络（RSN）功能连接是否存在不同的病变模式，以及识别由于性别导致的脑网络变化差异。
收集了 37 名正常对照（NC）、39 名早期 MCI（EMCI）患者和 37 名晚期 MCI（LMCI）患者的静息态功能磁共振成像（rs-fMRI）数据，并采用基于图论的网络模型，从三个方面比较了性别对不同阶段脑网络的影响：ROI 之间的功能连接、RSN 内的内功能连接以及 RSN 与白质（WM）之间的功能连接。
性别在 RSN 功能连接变化中起作用，包括 DMN、SMN、DAN 和 CON。女性 SMN 更易受损，DAN 与 WM 之间的功能连接损伤更严重。
在 MCI 进展过程中，男性和女性的 RSN 功能连接存在不同的病变模式，这表明在进行 MCI 进展研究和开发更有效的生物标志物以促进认知障碍和痴呆进展时，应充分考虑性别差异。
