人类脊柱骨密度与骨髓的准确关系。
The accurate relationship between spine bone density and bone marrow in humans.
机构信息
Department of Radiology, Beijing Jishuitan Hospital, Beijing 100035, China.
Department of Community Medical Care, Beijing Jishuitan Hospital, Beijing 100035, China.
出版信息
Bone. 2020 May;134:115312. doi: 10.1016/j.bone.2020.115312. Epub 2020 Mar 5.
CONTEXT
The accuracy of QCT measurements of lumbar spine trabecular volumetric bone mineral density (vBMD) is decreased due to differences in the amount of bone marrow adipose tissue (BMAT).
OBJECTIVE
To correct vBMD measurements for differences in marrow composition and investigate the true relationship between vBMD and BMAT.
DESIGN
Cross-sectional study.
SETTING
University teaching hospital.
PARTICIPANTS
Healthy Chinese subjects (233 women, 167 men) aged between 21 and 82 years.
MAIN OUTCOME MEASURES
vBMD and BMAT were measured using QCT (120 kV) and chemical shift-encoded MRI of the L2-L4 vertebrae. vBMD measurements were standardized to the European Spine Phantom (ESP) and corrected for differences in BMAT. Linear regression was used to analyze BMAT, ESP adjusted vBMD (vBMD) and BMAT corrected vBMD (vBMD) against age and corrected vBMD against BMAT.
RESULTS
BMAT in the L2-L4 vertebral bodies increased with age in both sexes, with a faster rate of change in women compared with men (0.54%/year vs. 0.27%/year, P < 0.0001). After vBMD measurements were corrected for BMAT there were statistically significant changes in the slope of the regression line with age in both sexes (women: -3.00 ± 0.13 vs. -2.57 ± 0.11 mg/cm/year, P < 0.0001; men: -1.92 ± 0.15 vs. -1.70 ± 0.14 mg/cm/year, P < 0.0001). When vBMD was plotted against BMAT, vBMD decreased linearly with increasing BMAT in both sexes (women: -3.30 ± 0.18 mg/cm/%; men: -2.69 ± 0.25 mg/cm/%, P = 0.048).
CONCLUSION
Our approach reveals the true relationship between vBMD and BMAT and provides a new tool for studying the interaction between bone and marrow adipose tissue.
背景
由于骨髓脂肪组织（BMAT）含量的差异，定量 CT（QCT）测量腰椎小梁容积骨矿物质密度（vBMD）的准确性降低。
目的
校正 vBMD 测量值以反映骨髓成分的差异，并研究 vBMD 与 BMAT 之间的真实关系。
设计
横断面研究。
地点
大学教学医院。
参与者
年龄在 21 至 82 岁之间的健康中国受试者（233 名女性，167 名男性）。
主要观察指标
通过 QCT（120kV）和 L2-L4 椎体化学位移编码 MRI 测量 vBMD 和 BMAT。将 vBMD 测量值标准化为欧洲脊柱体模（ESP），并校正 BMAT 差异。线性回归用于分析 BMAT、ESP 调整 vBMD（vBMD）和 BMAT 校正 vBMD（vBMD）与年龄的关系，以及校正 vBMD 与 BMAT 的关系。
结果
男女 L2-L4 椎体中的 BMAT 随年龄增长而增加，女性的变化速度快于男性（0.54%/年比 0.27%/年，P<0.0001）。校正 BMAT 后，男女 vBMD 测量值的回归线斜率随年龄发生显著变化（女性：-3.00±0.13 比-2.57±0.11 mg/cm/年，P<0.0001；男性：-1.92±0.15 比-1.70±0.14 mg/cm/年，P<0.0001）。当 vBMD 与 BMAT 作图时，男女 vBMD 均随 BMAT 线性下降（女性：-3.30±0.18 mg/cm/%；男性：-2.69±0.25 mg/cm/%，P=0.048）。
结论
我们的方法揭示了 vBMD 与 BMAT 之间的真实关系，并为研究骨与骨髓脂肪组织之间的相互作用提供了一种新的工具。
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