Shen Wei, Scherzer Rebecca, Gantz Madeleine, Chen Jun, Punyanitya Mark, Lewis Cora E, Grunfeld Carl
New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14H, New York, New York 10025, USA.
J Clin Endocrinol Metab. 2012 Apr;97(4):1337-46. doi: 10.1210/jc.2011-2605. Epub 2012 Feb 8.
An increasing number of studies suggest that bone marrow adipose tissue (BMAT) might play a role in the pathogenesis of osteoporosis. Our previous study of Caucasian women demonstrated that there is an inverse relationship between BMAT and whole-body bone mineral density (BMD). It is unknown whether visceral adipose tissue (VAT), sc adipose tissue (SAT), and skeletal muscle had an effect on the relationship between BMAT and BMD.
In the present study we investigated the relationship between pelvic, hip, and lumbar spine BMAT with hip and lumbar spine BMD in the population-based Coronary Artery Risk Development in Young Adults (CARDIA) sample with adjustment for whole-body magnetic resonance imaging (MRI)-measured VAT, SAT, and skeletal muscle.
T1-weighted MRI was acquired for 210 healthy African-American and Caucasian men and women (age 38-52 yr). Hip and lumbar spine BMD were measured by dual-energy x-ray absorptiometry.
Pelvic, hip, and lumbar spine BMAT had negative correlations with hip and lumbar spine BMD (r = -0.399 to -0.550, P < 0.001). The inverse associations between BMAT and BMD remained strong after adjusting for demographics, weight, skeletal muscle, SAT, VAT, total adipose tissue (TAT), menopausal status, lifestyle factors, and inflammatory markers (standardized regression coefficients = -0. 296 to -0.549, P < 0.001). Among body composition measures, skeletal muscle was the strongest correlate of BMD after adjusting for BMAT (standardized regression coefficients = 0.268-0.614, P < 0.05), with little additional contribution from weight, SAT, VAT, or total adipose tissue.
In this middle-aged population, a negative relationship existed between MRI-measured BMAT and hip and lumbar spine BMD independent of demographics and body composition. These observations support the growing evidence linking BMAT with low bone density.
越来越多的研究表明，骨髓脂肪组织（BMAT）可能在骨质疏松症的发病机制中起作用。我们之前对白人女性的研究表明，BMAT与全身骨密度（BMD）之间存在负相关关系。目前尚不清楚内脏脂肪组织（VAT）、皮下脂肪组织（SAT）和骨骼肌是否会影响BMAT与BMD之间的关系。
在本研究中，我们在基于人群的青年成人冠状动脉风险发展研究（CARDIA）样本中，对骨盆、髋部和腰椎的BMAT与髋部和腰椎的BMD之间的关系进行了研究，并对通过全身磁共振成像（MRI）测量的VAT、SAT和骨骼肌进行了校正。
对210名健康的非裔美国人和白人男性及女性（年龄38 - 52岁）进行了T1加权MRI检查。通过双能X线吸收法测量髋部和腰椎的BMD。
骨盆、髋部和腰椎的BMAT与髋部和腰椎的BMD呈负相关（r = -0.399至 -0.550，P < 0.001）。在对人口统计学、体重、骨骼肌、SAT、VAT、总脂肪组织（TAT）、绝经状态、生活方式因素和炎症标志物进行校正后，BMAT与BMD之间的负相关关系仍然很强（标准化回归系数 = -0.296至 -0.549，P < 0.001）。在身体成分测量中，校正BMAT后，骨骼肌是与BMD相关性最强的因素（标准化回归系数 = 0.268 - 0.614，P < 0.05），体重、SAT、VAT或总脂肪组织的额外贡献很小。
在这个中年人群中，MRI测量的BMAT与髋部和腰椎的BMD之间存在负相关关系，且独立于人口统计学和身体成分。这些观察结果支持了越来越多的将BMAT与低骨密度联系起来的证据。
