Toh Yi Long, Wang Claire, Ho Han Kiat, Chan Alexandre
Department of Pharmacy, National University of Singapore, Singapore.
Department of Pharmacy, National University of Singapore, Singapore; Department of Pharmacy, National Cancer Centre Singapore, Singapore; Department of Clinical Pharmacy Practice, University of California, Irvine, USA.
J Neuroimmunol. 2020 Feb 20;342:577196. doi: 10.1016/j.jneuroim.2020.577196.
The aim of the current study is to identify distinct cytokine profiles in relation to self-perceived cognitive trajectories. In our study cohort (n = 128), early-stage breast cancer patients were categorized into no impairment reported, acute, delayed, persistent and intermittent cognitive decline respectively. Pro-inflammatory cytokines were elevated compared to baseline; with TNF-α implicated in the acute cognitive trajectory while IL-6 and IL-8 were involved in the persistent cognitive trajectory. Our findings help to further our understanding of cytokine profiles implicated in cancer-related cognitive impairment (CRCI) and support the use of cytokine levels as biomarkers of cognitive decline over time.
本研究的目的是确定与自我感知的认知轨迹相关的不同细胞因子谱。在我们的研究队列（n = 128）中，早期乳腺癌患者分别被分类为未报告有损伤、急性、延迟、持续性和间歇性认知衰退。与基线相比，促炎细胞因子升高；肿瘤坏死因子-α与急性认知轨迹有关，而白细胞介素-6和白细胞介素-8与持续性认知轨迹有关。我们的研究结果有助于进一步了解与癌症相关的认知障碍（CRCI）中涉及的细胞因子谱，并支持将细胞因子水平用作随时间推移认知衰退的生物标志物。
