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DNA methylation age acceleration is associated with ALS age of onset and survival.

作者信息

Zhang Ming, McKeever Paul M, Xi Zhengrui, Moreno Danielle, Sato Christine, Bergsma Tessa, McGoldrick Philip, Keith Julia, Robertson Janice, Zinman Lorne, Rogaeva Ekaterina

机构信息

Shanghai First Rehabilitation Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave., Toronto, ON, M5T 2S8, Canada.

出版信息

Acta Neuropathol. 2020 May;139(5):943-946. doi: 10.1007/s00401-020-02131-z. Epub 2020 Mar 7.

DOI:10.1007/s00401-020-02131-z
PMID:32146547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7181538/
Abstract
摘要

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Reversal of epigenetic aging and immunosenescent trends in humans.人类表观遗传衰老和免疫衰老趋势的逆转。
Aging Cell. 2019 Dec;18(6):e13028. doi: 10.1111/acel.13028. Epub 2019 Sep 8.
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DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.DNA 甲基化时钟与衰老：分类、原因和后果。
Mol Cell. 2018 Sep 20;71(6):882-895. doi: 10.1016/j.molcel.2018.08.008.
3
Comorbidities.合并症
探索表观遗传修饰作为肌萎缩侧索硬化症潜在的生物标志物和治疗靶点。
J Neurol. 2025 Apr 1;272(4):304. doi: 10.1007/s00415-025-13028-w.
4
Whole-genome bisulfite sequencing of cell-free DNA unveils age-dependent and ALS-associated methylation alterations.游离DNA的全基因组亚硫酸氢盐测序揭示了年龄依赖性和肌萎缩侧索硬化症相关的甲基化改变。
Cell Biosci. 2025 Feb 20;15(1):26. doi: 10.1186/s13578-025-01366-1.
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The Promise of Epigenetic Editing for Treating Brain Disorders.表观遗传编辑治疗脑部疾病的前景
Subcell Biochem. 2025;108:111-190. doi: 10.1007/978-3-031-75980-2_4.
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repeat expansion creates the unstable folate-sensitive fragile site FRA9A.重复扩增产生不稳定的叶酸敏感脆性位点FRA9A。
NAR Mol Med. 2024 Nov 12;1(4):ugae019. doi: 10.1093/narmme/ugae019. eCollection 2024 Oct.
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Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis.表观遗传年龄加速与肌萎缩侧索硬化症中的职业暴露、性别和生存有关。
EBioMedicine. 2024 Nov;109:105383. doi: 10.1016/j.ebiom.2024.105383. Epub 2024 Oct 5.
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Causal associations and shared genetic etiology of neurodegenerative diseases with epigenetic aging and human longevity.神经退行性疾病与表观遗传衰老和人类长寿的因果关系及共同遗传病因。
Aging Cell. 2024 Nov;23(11):e14271. doi: 10.1111/acel.14271. Epub 2024 Sep 19.
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