Department of Internal Medicine, Mount Sinai Beth Israel/Icahn School of Medicine, New York, NY.
Adv Chronic Kidney Dis. 2020 Jan;27(1):38-49. doi: 10.1053/j.ackd.2019.08.005.
In the last several decades, advancements in chemotherapy have improved the overall survival of cancer patients. These agents, however, are associated with adverse effects, including various kidney lesions. This review summarizes the nephrotoxic potential of chemotherapy agents, old and new, as well as the different factors that contribute to kidney injury. Provided for each class of chemotherapy agent is the associated kidney lesion and a brief discussion of clinical manifestation, mechanism of action, and possible treatment when available. Understanding the nephrotoxic potential of these agents have on the kidneys is imperative for both the oncologist and the nephrologist to properly care for cancer patients and ensure their best outcomes.
在过去的几十年中，化疗的进步提高了癌症患者的总体生存率。然而，这些药物会产生不良反应，包括各种肾脏病变。本综述总结了化疗药物（新旧）的肾毒性潜力，以及导致肾损伤的不同因素。为每一类化疗药物提供了相关的肾脏病变，并简要讨论了临床表现、作用机制以及可能的治疗方法（如有）。了解这些药物对肾脏的肾毒性潜力对于肿瘤学家和肾病学家来说都是至关重要的，这样才能正确地照顾癌症患者并确保他们获得最佳的治疗效果。
