藏红花补充剂对腰围、HA1C 和葡萄糖代谢的影响：系统评价和随机临床试验荟萃分析。
The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials.
机构信息
Department of Community Nutrition, Student Research Committee, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Complement Ther Med. 2020 Mar;49:102298. doi: 10.1016/j.ctim.2020.102298. Epub 2020 Jan 7.
OBJECTIVE
Carotenoids (including zeaxanthin and lycopene) and phytosterols reportedly confer beneficial effects on metabolic profile and function, which is of clinical importance. Thus, we sought to review the saffron effects on waist circumstance (WC), fasting plasma glucose (FPG), and HA1C concentrations reported in Randomized Control Trials (RCTs).
METHOD
A comprehensive systematic electronic search was performed in PubMed/MEDLINE, Embase, Google Scholar, Cochrane, Web of sciences, and SCOPUS to identify RCTs up to February 2019 without any language restrictions. The pooled weighted mean difference (WMD) calculated with DerSimonian-Laird random. PRISMA guidelines adhered to for this meta-analysis.
RESULT
Nine articles with 12 arms containing 595 participants were included in this study. Our study found WC was significantly reduced (WMD: -2.18 cm, 95 % CI: -4.05, -0.32) and FPG (WMD: -6.54 mg/dl, 95 % CI: -10.22, -2.85) following saffron intervention. Subgroup analysis highlighted that FPG levels (WMD: -10.24 mg/dl, 95 % CI: -15.76, -4.72) reduced significantly when intervention duration was longer than twelve weeks. There was no significant effect on HA1C levels (WMD: -0.13 mg/dl, 95 % CI: -0.31, 0.04) following saffron intervention.
CONCLUSION
In conclusion, the present study indicates beneficial effects on WC and FPG, following saffron supplementation.
目的
类胡萝卜素（包括玉米黄质和番茄红素）和植物固醇据称对代谢谱和功能有有益影响，这具有临床重要性。因此，我们试图综述藏红花对随机对照试验（RCT）中腰围（WC）、空腹血糖（FPG）和 HA1C 浓度的影响。
方法
我们在 PubMed/MEDLINE、Embase、Google Scholar、Cochrane、Web of sciences 和 SCOPUS 中进行了全面的系统电子检索，以确定截至 2019 年 2 月的 RCT，不限制任何语言。采用 DerSimonian-Laird 随机方法计算汇总加权均数差（WMD）。本荟萃分析遵循 PRISMA 指南。
结果
本研究纳入了 9 篇文章的 12 个试验臂，共包含 595 名参与者。我们的研究发现，藏红花干预后 WC 明显降低（WMD：-2.18cm，95%CI：-4.05，-0.32），FPG（WMD：-6.54mg/dl，95%CI：-10.22，-2.85）也降低。亚组分析表明，干预持续时间超过 12 周时，FPG 水平（WMD：-10.24mg/dl，95%CI：-15.76，-4.72）显著降低。藏红花干预后，HA1C 水平无显著变化（WMD：-0.13mg/dl，95%CI：-0.31，0.04）。
结论
综上所述，本研究表明藏红花补充剂具有降低 WC 和 FPG 的有益作用。
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