藏红花补充剂对成年人血压的影响：随机对照试验的系统评价和剂量反应荟萃分析。

The Effect of Saffron Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.

机构信息

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran 14176-13151, Iran.

Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran.

出版信息

Nutrients. 2021 Aug 9;13(8):2736. doi: 10.3390/nu13082736.

BACKGROUND

The favorable influences of saffron supplementation on metabolic diseases have previously been shown. We aimed to assess the effects of saffron supplementation on blood pressure in adults.

METHODS

A systematic search was performed in Scopus, Embase, and the Cochrane library databases to find randomized controlled trials (RCTs) related to the effect of saffron supplementation on blood pressure in adults up to March 2021. The primary search yielded 182 publications, of which eight RCTs were eligible.

RESULTS

Our results showed that saffron supplementation resulted in a significant decrease in systolic blood pressure (weighted mean difference (WMD): -0.65 mmHg; 95% CI: -1.12 to -0.18, = 0.006) and diastolic blood pressure (DBP) (WMD: -1.23 mmHg; 95% CI: -1.64 to -0.81, < 0.001). Moreover, saffron supplementation reduced DBP in a non-linear fashion, based on duration (r = -2.45, -nonlinearity = 0.008).

CONCLUSIONS

Saffron supplementation may significantly improve both systolic and diastolic blood pressure in adults. It should be noted that the hypotensive effects of saffron supplementation were small and may not reach clinical importance.

背景

先前已经证明，藏红花补充剂对代谢疾病有有益影响。我们旨在评估藏红花补充剂对成年人血压的影响。

方法

我们在 Scopus、Embase 和 Cochrane 图书馆数据库中进行了系统检索，以查找截至 2021 年 3 月有关藏红花补充剂对成年人血压影响的随机对照试验（RCT）。初步检索产生了 182 篇出版物，其中有 8 项 RCT 符合条件。

结果

我们的结果表明，藏红花补充剂可显著降低收缩压（加权均数差值（WMD）：-0.65mmHg；95%置信区间（CI）：-1.12 至-0.18， = 0.006）和舒张压（WMD：-1.23mmHg；95%CI：-1.64 至-0.81， < 0.001）。此外，根据持续时间，藏红花补充剂以非线性方式降低舒张压（r = -2.45，非线性 = 0.008）。