Yagi H, Katoh S, Akiguchi I, Takeda T
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Brain Res. 1988 Nov 22;474(1):86-93. doi: 10.1016/0006-8993(88)90671-3.
Memory, learning and behavior of senescence accelerated mouse (SAM-P/8) were investigated by using passive avoidance response, T-maze and open field and the findings were compared with those from senescence resistant mouse (SAM-R/1 control). SAM-P/8 mice showed a remarkable age-related deterioration in ability of memory and learning in passive avoidance response. This age-related memory and learning deficit was linked to a deterioration in the ability of acquisition and was not due to impairment in the ability of retention and hyperactivity, as observed in the open field. In the alternation T-maze tests, SAM-P/8 showed as high a rate of alternations as did the SAM-R/1 and in the T-maze avoidance tests, SAM-P/8 also showed as intact a memory ability as seen in the SAM-R/1, despite a memory deficit in the passive avoidance response. Thus, SAM-P/8 may prove to be a pertinent model for researching mechanisms related to the memory deficit seen in senile humans.
采用被动回避反应、T迷宫和旷场实验，对快速老化小鼠（SAM-P/8）的记忆、学习和行为进行了研究，并将研究结果与抗老化小鼠（SAM-R/1对照组）的结果进行了比较。SAM-P/8小鼠在被动回避反应中的记忆和学习能力呈现出显著的与年龄相关的衰退。这种与年龄相关的记忆和学习缺陷与获得能力的衰退有关，而不是像在旷场实验中观察到的那样，是由于保持能力受损和多动所致。在交替T迷宫实验中，SAM-P/8的交替率与SAM-R/1一样高；在T迷宫回避实验中，尽管SAM-P/8在被动回避反应中存在记忆缺陷，但其记忆能力与SAM-R/1一样完好。因此，SAM-P/8可能被证明是研究老年人类记忆缺陷相关机制的一个合适模型。
