Ohta A, Hirano T, Yagi H, Tanaka S, Hosokawa M, Takeda T
Department of Psychology, Faculty of Letters, Kyoto University, Japan.
Brain Res. 1989 Sep 25;498(1):195-8. doi: 10.1016/0006-8993(89)90421-6.
The behavior of the senescence-accelerated mouse (SAM-P/8) at the age of 1, 2, 4 and 10-11 months in Sidman active avoidance learning was analyzed, and compared to findings in the controls (SAM-R/1). At the age of 1 and 2 months, learning was comparable in these two strains. At the age of 4 and 10-11 months, SAM-P/8 but not SAM-R/1 learned active avoidance. We propose that SAM-P/8 can serve as a valid model of deficits in learning and memory.
分析了衰老加速小鼠（SAM-P/8）在1、2、4和10 - 11月龄时在西德曼主动回避学习中的行为，并与对照组（SAM-R/1）的结果进行比较。在1和2月龄时，这两个品系的学习情况相当。在4和10 - 11月龄时，SAM-P/8学会了主动回避，而SAM-R/1没有。我们认为SAM-P/8可作为学习和记忆缺陷的有效模型。
