Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut.
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut.
World Neurosurg. 2020 Jun;138:e515-e522. doi: 10.1016/j.wneu.2020.02.158. Epub 2020 Mar 5.
For adult patients undergoing surgical decompression for Chiari malformation type I (CM-I), the patient-level factors that influence extended length of stay (LOS) are relatively unknown. The aim of this study was to investigate the impact of patient-baseline comorbidities, demographics, and postoperative complications on extended LOS after intervention after adult CM-I decompression surgery.
A retrospective cohort study using the National Inpatient Sample years 2010-2014 was performed. Adults (≥18 years) with a primary diagnosis of CM-I undergoing surgical decompression were identified. Weighted patient demographics, comorbidities, complications, LOS, disposition, and total cost were recorded. A multivariate logistic regression was used to determine the odds ratio for risk-adjusted LOS.
A total of 29,961 patients were identified, 6802 of whom (22.7%) had extended LOS. The extended LOS cohort had a significantly greater overall complication rate (normal LOS, 10.6% vs. extended LOS, 29.1%; P < 0.001) and total cost (normal LOS, $14,959 ± $6037 vs. extended LOS, $25,324 ± $21,629; P < 0.001) compared with the normal LOS cohort. On multivariate logistic regression, black race, income quartiles, private insurance, obstructive hydrocephalus, lack of coordination, fluid and electrolyte disorders, and paralysis were all independently associated with extended LOS. Additional duraplasty (P = 0.132) was not significantly associated with extended LOS after adjusting for other variables. The odds ratio for extended LOS was 2.07 (95% confidence interval, 1.59-2.71) for patients with 1 complication and 9.47 (95% confidence interval, 5.86-15.30) for patients with >1 complication.
Our study shows that extended LOS after adult CM-I decompression surgery may be influenced by multiple patient-level factors.
对于接受手术减压治疗 Chiari 畸形 I 型(CM-I)的成年患者,影响住院时间延长(LOS)的患者因素尚不清楚。本研究旨在探讨患者基线合并症、人口统计学和术后并发症对成人 CM-I 减压手术后 LOS 延长的影响。
使用 2010-2014 年国家住院患者样本进行回顾性队列研究。确定患有原发性 CM-I 并接受手术减压的成年人(≥18 岁)。记录了加权患者人口统计学、合并症、并发症、LOS、处置和总费用。使用多变量逻辑回归确定风险调整 LOS 的优势比。
共确定了 29961 例患者,其中 6802 例(22.7%)有 LOS 延长。LOS 延长组的总体并发症发生率(正常 LOS,10.6% vs. LOS 延长,29.1%;P<0.001)和总费用(正常 LOS,$14959 ± $6037 vs. LOS 延长,$25324 ± $21629;P<0.001)明显高于正常 LOS 组。多变量逻辑回归显示,黑人种族、收入四分位数、私人保险、梗阻性脑积水、协调障碍、液体和电解质紊乱以及瘫痪均与 LOS 延长独立相关。在调整其他变量后,额外的硬脑膜成形术(P=0.132)与 LOS 延长无显著相关性。并发症 1 例患者的 LOS 延长比值比为 2.07(95%置信区间,1.59-2.71),并发症>1 例患者的 LOS 延长比值比为 9.47(95%置信区间,5.86-15.30)。
我们的研究表明,成人 CM-I 减压手术后 LOS 延长可能受到多个患者水平因素的影响。