Gardner D
Department of Physiology, Cornell University Medical College, New York, NY 10021.
Brain Res Bull. 1988 Sep;21(3):521-8. doi: 10.1016/0361-9230(88)90168-2.
A modification of Klopf's heterostatic adaptive neuron hypothesis is proposed, in which membrane potential variance, rather than depolarization, has adaptive influence on individual nerve cells. Recordings from each of two configurations of three-cell networks of Aplysia buccal ganglia test for either nonspecific or associative effects of excess membrane potential and current variance, in the form of noise injection into voltage-clamped postsynaptic neurons. No effects of noise are reported, suggesting either that the hypothesis is incorrect, or else that the frequency spectrum or duration of recording were inappropriate to produce the adaptive modulation.
本文提出了对克洛普夫异稳态适应性神经元假说的一种修正，即膜电位方差而非去极化对单个神经细胞具有适应性影响。以向电压钳制的突触后神经元注入噪声的形式，对海兔口神经节三细胞网络的两种配置进行记录，以测试过量膜电位和电流方差的非特异性或联合效应。未报告噪声效应，这表明要么该假说是错误的，要么记录的频谱或持续时间不适于产生适应性调制。
