Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
EMBO Rep. 2020 Apr 3;21(4):e50190. doi: 10.15252/embr.202050190. Epub 2020 Mar 9.
Efficient antibody production is a crucial step during immune responses leading to pathogen clearance and neutralization. Immune synapses, contact points between T and B lymphocytes in the presence of an antigen, are necessary to initiate the proliferation and differentiation of B cells in the germinal center. In this issue of EMBO Reports, Fernández-Messina et al [1] present evidence of microRNA transfer from T to B cells via exosomes during synapse formation and highlight the crucial role of these exosomes for germinal center formation and the efficient production of antigen-specific antibodies.
高效的抗体产生是免疫反应中清除和中和病原体的关键步骤。免疫突触是抗原存在时 T 细胞和 B 细胞之间的接触点,对于启动生发中心 B 细胞的增殖和分化是必需的。在本期的《EMBO 报告》中,Fernández-Messina 等人[1]提出了证据,表明在突触形成过程中,T 细胞通过外泌体将 microRNA 转移到 B 细胞中,并强调了这些外泌体对于生发中心形成和高效产生抗原特异性抗体的关键作用。